Evidence map›Paper›PMID 34638955›Full record

ArticleInternational journal of molecular sciences2021

Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.

Anna Katharina Spohner, Katja Jakobi, Sandra Trautmann, Dominique Thomas, Fabian Schumacher, Burkhard Kleuser, Dieter Lütjohann, Khadija El-Hindi, Sabine Grösch, Josef Pfeilschifter and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. A role for plasma membrane CaPflugers Archiv : European journal of physiology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Anna Katharina SpohnerInstitut für Allgemeine Pharmakologie und Toxikologie, Universitätsklinikum, Goethe-Universität Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Katja JakobiInstitut für Allgemeine Pharmakologie und Toxikologie, Universitätsklinikum, Goethe-Universität Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Sandra TrautmannInstitut für Klinische Pharmakologie, Universitätsklinikum, Goethe-Universität Frankfurt am Main, Theo-dor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Dominique ThomasInstitut für Klinische Pharmakologie, Universitätsklinikum, Goethe-Universität Frankfurt am Main, Theo-dor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-4153-3669
Fabian SchumacherInstitut für Pharmazie, Pharmakologie und Toxikologie, Freie Universität Berlin, Königin-Luise-Straße 2-4, 14195 Berlin, Germany.ORCID 0000-0001-8703-3275
Burkhard KleuserInstitut für Pharmazie, Pharmakologie und Toxikologie, Freie Universität Berlin, Königin-Luise-Straße 2-4, 14195 Berlin, Germany.ORCID 0000-0002-1888-9595
Dieter LütjohannInstitut für Klinische Chemie und Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Khadija El-HindiInstitut für Klinische Pharmakologie, Universitätsklinikum, Goethe-Universität Frankfurt am Main, Theo-dor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Sabine GröschInstitut für Klinische Pharmakologie, Universitätsklinikum, Goethe-Universität Frankfurt am Main, Theo-dor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-7262-6307
Josef PfeilschifterInstitut für Allgemeine Pharmakologie und Toxikologie, Universitätsklinikum, Goethe-Universität Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Julie D SabaDepartment of Pediatrics, Division of Hematology/Oncology, University of California, 505 Parnassus Ave, San Francisco, CA 94143, USA.
Dagmar Meyer Zu HeringdorfInstitut für Allgemeine Pharmakologie und Toxikologie, Universitätsklinikum, Goethe-Universität Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.ORCID 0000-0003-1246-9677
Goethe University Frankfurt · DEFreie Universität Berlin · DEUniversity Hospital Bonn · DEUniversity of California, San Francisco · US

Funding

Endogenous and Dietary Sphingolipids as Modulators of Inflammatory Bowel DiseaseR01DK115669 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SABA, JULIE D · 2018 to 2021
$1.8M
NIDDK NIH HHS R01 DK115669NIH HHS R01 DK115669
6 · The paper itself

Abstract

Sphingosine 1 phosphate (S1P) lyase (

Indexed as

Aldehyde-LyasesAnimalsBileCells, CulturedCeramidesCholesterol, LDLGene Knockout TechniquesHepatocytesHomeostasisLiverLysophospholipidsMiceMice, KnockoutPhenotypeReceptors, LDLSphingolipidsAldehyde-LyasesCeramidesCholesterol, LDLLysophospholipidsReceptors, LDLSgpl1 protein, mouseSphingolipidsSphingosinesphingosine 1-phosphatebileceramidescholesterolliverSGPL1sphingosine-1-phosphate

Identifiers

PMID34638955
PMCPMC8508615
OpenAlexW3201893384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.