Evidence map›Paper›PMID 34638937›Full record

ArticleInternational journal of molecular sciences2021

Piceatannol, a Structural Analog of Resveratrol, Is an Apoptosis Inducer and a Multidrug Resistance Modulator in HL-60 Human Acute Myeloid Leukemia Cells.

Kamila Siedlecka-Kroplewska, Agata Wrońska, Zbigniew Kmieć

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  7. Metabolic Engineering ofMolecules (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Article
  10. Molecular Mechanisms and Therapies of Myeloid Leukaemia.International journal of molecular sciences · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kamila Siedlecka-KroplewskaDepartment of Histology, Medical University of Gdańsk, 80-211 Gdańsk, Poland.ORCID 0000-0002-6313-0799
Agata WrońskaDepartment of Histology, Medical University of Gdańsk, 80-211 Gdańsk, Poland.ORCID 0000-0003-1792-8975
Zbigniew KmiećDepartment of Histology, Medical University of Gdańsk, 80-211 Gdańsk, Poland.ORCID 0000-0002-9801-8166
Gdańsk Medical University · PL

Funding

Medical University of Gdańsk (Gdańsk, Poland) and Polish Ministry of Science and Higher Education MN grant no. 01-0173/08/280
6 · The paper itself

Abstract

Acute myeloid leukemia is characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells. Despite recent advances in the treatment of this disease, the prognosis and overall long-term survival for patients remain poor, which drives the search for new chemotherapeutics and treatment strategies. Piceatannol, a polyphenolic compound present in grapes and wine, appears to be a promising chemotherapeutic agent in the treatment of leukemia. The aim of the present study was to examine whether piceatannol induces autophagy and/or apoptosis in HL-60 human acute myeloid leukemia cells and whether HL-60 cells are able to acquire resistance to piceatannol toxicity. We found that piceatannol at the IC

Indexed as

Antineoplastic AgentsApoptosisATP Binding Cassette Transporter, Subfamily B, Member 1AutophagyCaspase 3Cell CycleCell SurvivalDNA FragmentationDrug Resistance, MultipleHL-60 CellsHumansInhibitory Concentration 50Leukemia, Myeloid, AcuteMembrane Potential, MitochondrialMolecular StructureReactive Oxygen Species3,3',4,5'-tetrahydroxystilbeneAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1CASP3 protein, humanCaspase 3Reactive Oxygen SpeciesResveratrolStilbenesacute myeloid leukemiaapoptosisBCRPHL-60 cellsMRP1multidrug resistanceP-glycoproteinpiceatannol

Identifiers

PMID34638937
PMCPMC8509003
OpenAlexW3202906507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.