ArticleInternational journal of molecular sciences2021
Dependence of Graphene Oxide (GO) Toxicity on Oxidation Level, Elemental Composition, and Size.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Toxic or non-toxic: a critical assessment of the contradictory results for selected graphene family materials.Frontiers in toxicology · 2026Review
- Graphene-Based Materials: A Multifunctional Platform for Comprehensive Perioperative Management of Cancer.International journal of nanomedicine · 2026Review
- Graphene Oxide-Enriched Polymer: Impact on Dental Pulp Cell Viability and Differentiation.Polymers · 2025Article
- Biosafety and Blood Compatibility of Graphene Oxide Particles in In Vitro Experiments.Materials (Basel, Switzerland) · 2025Article
- The Role and Future of Functional Graphenic Materials in Biomedical and Human Health Applications.Biomacromolecules · 2025Review
- Exploring the Capabilities of Nanosized Graphene Oxide as a Pesticide Nanosorbent: Simulation Studies.ACS omega · 2025Article
- Angiotensin II-Induced Hypertrophy in H9c2 Cells Reveals Severe Cytotoxicity of Graphene Oxide.ACS omega · 2025Article
- Advanced Low-Dimensional Carbon Nanomaterials for Oxygen Electrocatalysis.Nanomaterials (Basel, Switzerland) · 2025Review
- A Novel Concept of Nano-Enhanced Phase Change Material.Materials (Basel, Switzerland) · 2024Article
- Amplified and distinctive genotoxicity of titanium dioxide nanoparticles in transformed yeast reporters with human cytochrome P450 (CYP) genes.Journal of hazardous materials · 2024Article
- Silver and Carbon Nanomaterials/Nanocomplexes as Safe and Effective ACE2-S Binding Blockers on Human Skin Cell Lines.Molecules (Basel, Switzerland) · 2024Article
- 3D-printed PCL framework assembling ECM-inspired multi-layer mineralized GO-Col-HAp microscaffold for in situ mandibular bone regeneration.Journal of translational medicine · 2024Article
- Cytotoxicity of Carbon Nanotubes, Graphene, Fullerenes, and Dots.Nanomaterials (Basel, Switzerland) · 2023Review
- Effect of graphene-based nanomaterials on corneal wound healing in vitro.Experimental eye research · 2023Article
- Toxicogenomics and Molecular Markers in Pollution.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
The mass production of graphene oxide (GO) unavoidably elevates the chance of human exposure, as well as the possibility of release into the environment with high stability, raising public concern as to its potential toxicological risks and the implications for humans and ecosystems. Therefore, a thorough assessment of GO toxicity, including its potential reliance on key physicochemical factors, which is lacking in the literature, is of high significance and importance. In this study, GO toxicity, and its dependence on oxidation level, elemental composition, and size, were comprehensively assessed. A newly established quantitative toxicogenomic-based toxicity testing approach, combined with conventional phenotypic bioassays, were employed. The toxicogenomic assay utilized a GFP-fused yeast reporter library covering key cellular toxicity pathways. The results reveal that, indeed, the elemental composition and size do exert impacts on GO toxicity, while the oxidation level exhibits no significant effects. The UV-treated GO, with significantly higher carbon-carbon groups and carboxyl groups, showed a higher toxicity level, especially in the protein and chemical stress categories. With the decrease in size, the toxicity level of the sonicated GOs tended to increase. It is proposed that the covering and subsequent internalization of GO sheets might be the main mode of action in yeast cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.