Evidence map›Paper›PMID 34638900›Full record

ArticleInternational journal of molecular sciences2021

Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury.

Jenni Kyyriäinen, Natallie Kajevu, Ivette Bañuelos, Leonardo Lara, Anssi Lipponen, Silvia Balosso, Elina Hämäläinen, Shalini Das Gupta, Noora Puhakka, Teemu Natunen and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. N-Acetylcysteine and Probenecid Adjuvant Therapy for Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Jenni KyyriäinenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0002-8396-6921
Natallie KajevuA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
Ivette BañuelosA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0002-1474-3513
Leonardo LaraA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0003-4617-2580
Anssi LipponenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0002-4403-9084
Silvia BalossoDepartment of Neuroscience, Mario Negri Institute for Pharmacological Research IRCCS, 20156 Milano, Italy.
Elina HämäläinenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0001-6869-2574
Shalini Das GuptaA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
Noora PuhakkaA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
Teemu NatunenInstitute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
Teresa RavizzaDepartment of Neuroscience, Mario Negri Institute for Pharmacological Research IRCCS, 20156 Milano, Italy.ORCID 0000-0002-9578-018X
Annamaria VezzaniDepartment of Neuroscience, Mario Negri Institute for Pharmacological Research IRCCS, 20156 Milano, Italy.
Mikko HiltunenInstitute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0003-3566-4096
Asla PitkänenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0002-8163-5416
University of Eastern Finland · FIMario Negri Institute for Pharmacological Research · IT

Funding

Academy of Finland 2285733-9Academy of Finland 272249Academy of Finland 273909Academy of Finland 307866FP7-HEALTH project 602102 (EPITARGET) 602102Sigrid Juséliuksen Säätiö 0000Strategic Neuroscience Funding of the University of Eastern Finland 0000
6 · The paper itself

Abstract

We assessed the effect of antioxidant therapy using the Food and Drug Administration-approved respiratory drug

Indexed as

AcetylcysteineAnimalsAntioxidantsBrainBrain Injuries, TraumaticCell LineCells, CulturedCell SurvivalDisease Models, AnimalGene ExpressionHeme Oxygenase-1IsothiocyanatesMaleMiceMice, Inbred C57BLMicrogliaAcetylcysteineAntioxidantsHeme Oxygenase-1IsothiocyanatesNF-E2-Related Factor 2sulforaphaneSulfoxidesantioxidant treatmentcytokinelateral fluid-percussion injuryN-acetylcysteineoxidative stresssulforaphane

Identifiers

PMID34638900
PMCPMC8508668
OpenAlexW3202942986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.