Evidence map›Paper›PMID 34638891›Full record

ReviewInternational journal of molecular sciences2021

Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids.

Margalida Torrens-Mas, Catalina Perelló-Reus, Cayetano Navas-Enamorado, Lesly Ibargüen-González, Andres Sanchez-Polo, Juan Jose Segura-Sampedro, Luis Masmiquel, Carles Barcelo, Marta Gonzalez-Freire

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Animal organoids as models for integrated One Health research.One health (Amsterdam, Netherlands) · 2026
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  5. Translational Geroscience Strategies for Delaying Multimorbidity.ACS pharmacology & translational science · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Margalida Torrens-MasVascular and Metabolic Pathologies Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.ORCID 0000-0002-2983-1620
Catalina Perelló-ReusTranslational Pancreatic Cancer Oncogenesis Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Cayetano Navas-EnamoradoVascular and Metabolic Pathologies Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Lesly Ibargüen-GonzálezTranslational Pancreatic Cancer Oncogenesis Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Andres Sanchez-PoloVascular and Metabolic Pathologies Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Juan Jose Segura-SampedroTranslational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.ORCID 0000-0003-0565-3791
Luis MasmiquelVascular and Metabolic Pathologies Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.ORCID 0000-0002-6549-5652
Carles BarceloTranslational Pancreatic Cancer Oncogenesis Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Marta Gonzalez-FreireVascular and Metabolic Pathologies Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.ORCID 0000-0001-9741-2826

Funding

Comunidad Autonoma de las Islas Baleares, Margalida Comas Program PD/050/2020Impost turisme sostenible/Govern de les Illes Balears FOLIUM 19/01Impost turisme sostenible/Govern de les Illes Balears TECH19/03Instituto de Salud Carlos III COV20/00571Instituto de Salud Carlos III MS19/00201; MS19/00100; PI20/01267;
6 · The paper itself

Abstract

The biology of aging is focused on the identification of novel pathways that regulate the underlying processes of aging to develop interventions aimed at delaying the onset and progression of chronic diseases to extend lifespan. However, the research on the aging field has been conducted mainly in animal models, yeast,

Indexed as

AgingAnimalsCell Culture TechniquesEpigenomicsGenomic InstabilityGenomicsHumansModels, GeneticNeoplasmsOrganoidsagingorganoidsprecision medicine

Identifiers

PMID34638891
PMCPMC8508868

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.