Evidence map›Paper›PMID 34638866›Full record

ArticleInternational journal of molecular sciences2021

Sequestration of RBM10 in Nuclear Bodies: Targeting Sequences and Biological Significance.

Ling-Yu Wang, Sheng-Jun Xiao, Hiroyuki Kunimoto, Kazuaki Tokunaga, Hirotada Kojima, Masatsugu Kimura, Takahiro Yamamoto, Naoki Yamamoto, Hong Zhao, Koji Nishio and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Ling-Yu WangDepartment of Immunology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
Sheng-Jun XiaoDepartment of Immunology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.ORCID 0000-0001-6731-1899
Hiroyuki KunimotoDepartment of Immunology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
Kazuaki TokunagaDepartment of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan.
Hirotada KojimaDepartment of Immunology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
Masatsugu KimuraRadioisotope Center, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
Takahiro YamamotoGraduate School of Life Science, Hokkaido University, Sapporo 060-0808, Japan.
Naoki YamamotoCenter for Basic Medical Research, and Graduate School of Pharmaceutical Sciences, International University of Health and Welfare, Ohtawara 324-8501, Japan.ORCID 0000-0003-4208-9392
Hong ZhaoDepartment of Immunology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
Koji NishioDepartment of Anatomy and Neurosciences, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Tokio TaniDepartment of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan.
Koichi NakajimaDepartment of Immunology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
Kishiko SunamiDepartment of Otolaryngology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
Akira InoueDepartment of Immunology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.ORCID 0000-0002-1938-656X
Osaka City University · JPGuilin Medical University · CNKumamoto University · JPHokkaido University · JPNagoya University · JPTokyo Metropolitan University · JP

Funding

Japan Society for the Promotion of Science 21550162, J152640005, 15K05569, and 19K08378
6 · The paper itself

Abstract

RBM10 is an RNA-binding protein that regulates alternative splicing (AS). It localizes to the extra-nucleolar nucleoplasm and S1-1 nuclear bodies (NBs) in the nucleus. We investigated the biological significance of this localization in relation to its molecular function. Our analyses, employing deletion mutants, revealed that RBM10 possesses two S1-1 NB-targeting sequences (NBTSs), one in the KEKE motif region and another in the C

Indexed as

Alternative SplicingAmino Acid MotifsCell NucleusHEK293 CellsHeLa CellsHep G2 CellsHumansNuclear Localization SignalsProtein DomainsProtein TransportRNA-Binding ProteinsNuclear Localization SignalsRBM10 protein, humanRNA-Binding Proteinsalternative splicingC2H2 Zn fingernuclear body-targeting sequenceRBM10S1-1 nuclear bodytranscription

Identifiers

PMID34638866
PMCPMC8508765
OpenAlexW3204802267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.