Evidence map›Paper›PMID 34638830›Full record

ArticleInternational journal of molecular sciences2021

Establishment of Bovine-Induced Pluripotent Stem Cells.

Yue Su, Ling Wang, Zhiqiang Fan, Ying Liu, Jiaqi Zhu, Deborah Kaback, Julia Oudiz, Tayler Patrick, Siu Pok Yee, Xiuchun Cindy Tian and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Scaling Cultured Meat: Challenges and Solutions for Affordable Mass Production.Comprehensive reviews in food science and food safety · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. H3K9me3 Levels Affect the Proliferation of Bovine Spermatogonial Stem Cells.International journal of molecular sciences · 2024
    Article
  14. Review
  15. Bovine Pluripotent Stem Cells: Current Status and Prospects.International journal of molecular sciences · 2024
    Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yue SuDepartment of Animal Science, Institute of Systems Genetics, University of Connecticut, Storrs, CT 06268, USA.
Ling WangDepartment of Animal Science, Institute of Systems Genetics, University of Connecticut, Storrs, CT 06268, USA.ORCID 0000-0002-0787-3352
Zhiqiang FanDepartment of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA.
Ying LiuDepartment of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA.ORCID 0000-0002-5680-5110
Jiaqi ZhuDepartment of Animal Science, Institute of Systems Genetics, University of Connecticut, Storrs, CT 06268, USA.
Deborah KabackDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Julia OudizDepartment of Animal Science, Institute of Systems Genetics, University of Connecticut, Storrs, CT 06268, USA.
Tayler PatrickDepartment of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA.ORCID 0000-0001-7989-9634
Siu Pok YeeDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Xiuchun Cindy TianDepartment of Animal Science, Institute of Systems Genetics, University of Connecticut, Storrs, CT 06268, USA.
Irina PolejaevaDepartment of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA.
Young TangDepartment of Animal Science, Institute of Systems Genetics, University of Connecticut, Storrs, CT 06268, USA.ORCID 0000-0001-6188-7758
University of Connecticut · USUtah State University · USUConn Health · US

Funding

USDA National Institute of Food and Agriculture Agriculture and Food Research Initiative Competitive Grant no. 2016-67016-24894 and no. 2019-67015-29413
6 · The paper itself

Abstract

Pluripotent stem cells (PSCs) have been successfully developed in many species. However, the establishment of bovine-induced pluripotent stem cells (biPSCs) has been challenging. Here we report the generation of biPSCs from bovine mesenchymal stem cells (bMSCs) by overexpression of lysine-specific demethylase 4A (KDM4A) and the other reprogramming factors OCT4, SOX2, KLF4, cMYC, LIN28, and NANOG (K

Indexed as

Cellular Reprogramming TechniquesAnimalsCattleGene Expression ProfilingInduced Pluripotent Stem CellsKruppel-Like Factor 4Mesenchymal Stem CellsMiceTranscription FactorsKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Transcription Factorsbovinedifferentiationembryo aggregationinduced pluripotent stem cells (iPSCs)nuclear transfer (NT)pluripotencyreprogramming

Identifiers

PMID34638830
PMCPMC8508593
OpenAlexW3204307479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.