Evidence map›Paper›PMID 34638773›Full record

ArticleInternational journal of molecular sciences2021

Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy.

Edgar Ontsouka, Alessandra Epstein, Sampada Kallol, Jonas Zaugg, Marc Baumann, Henning Schneider, Christiane Albrecht

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Intrahepatic cholestasis of pregnancy.Nature reviews. Disease primers · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Bile Acids in Intrahepatic Cholestasis of Pregnancy.Diagnostics (Basel, Switzerland) · 2022
    Review
  16. Placental Related Disorders of Pregnancy.International journal of molecular sciences · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Edgar OntsoukaInstitute of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Alessandra EpsteinInstitute of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Sampada KallolInstitute of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Jonas ZauggInstitute of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.ORCID 0000-0002-3153-2806
Marc BaumannDepartment of Obstetrics and Gyneacology, University Hospital, Effingerstrasse 102, 3010 Bern, Switzerland.ORCID 0000-0002-4696-5700
Henning SchneiderDepartment of Obstetrics and Gyneacology, University Hospital, Effingerstrasse 102, 3010 Bern, Switzerland.
Christiane AlbrechtInstitute of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.ORCID 0000-0002-7846-6930
University of Bern · CHUniversity Hospital of Bern · CH

Funding

NCCR TransCure 51NF40-185544Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_149958
6 · The paper itself

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-related condition characterized by increased maternal circulating bile acids (BAs) having adverse fetal effects. We investigated whether the human placenta expresses specific regulation patterns to prevent fetal exposition to harmful amounts of BAs during ICP. Using real-time quantitative PCR, we screened placentae from healthy pregnancies (

Indexed as

Gene Expression RegulationCarrier ProteinsCholestasis, IntrahepaticFemaleHumansMembrane GlycoproteinsMultidrug Resistance-Associated Protein 2PlacentaPregnancyPregnancy ComplicationsABCC2 protein, humanbile acid binding proteinsCarrier ProteinsMembrane GlycoproteinsMultidrug Resistance-Associated Protein 2bile acidshuman placentaintrahepatic cholestasis of pregnancypregnancy complicationstransporters

Identifiers

PMID34638773
PMCPMC8508908
OpenAlexW3204099318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.