Evidence map›Paper›PMID 34638752›Full record

ArticleInternational journal of molecular sciences2021

EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways.

Huey-Jen Tsay, Hui-Kang Liu, Yueh-Hsiung Kuo, Chuan-Sheng Chiu, Chih-Chiang Liang, Chen-Wei Chung, Chin-Chu Chen, Yen-Po Chen, Young-Ji Shiao

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  6. The mechanisms ofJournal of dental sciences · 2024
    Article
  7. Neural Correlates and Molecular Mechanisms of Memory and Learning.International journal of molecular sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Huey-Jen TsayInstitute of Neuroscience, School of Life Science, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Hui-Kang LiuNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.ORCID 0000-0002-5297-6836
Yueh-Hsiung KuoDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan.ORCID 0000-0001-5935-6755
Chuan-Sheng ChiuInstitute of Biopharmaceutical Science, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Chih-Chiang LiangInstitute of Anatomy and Cell Biology, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Chen-Wei ChungInstitute of Traditional Medicine, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Chin-Chu ChenBiotech Research Institute, Grape King Bio Ltd., Taoyuan City 320, Taiwan.
Yen-Po ChenBiotech Research Institute, Grape King Bio Ltd., Taoyuan City 320, Taiwan.
Young-Ji ShiaoNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.ORCID 0000-0002-2699-116X
National Yang Ming Chiao Tung University · TWGrape King (Taiwan) · TWAsia University · TWNational Research Institute of Chinese Medicine · TW

Funding

Ministry of Science and Technology Taiwan MOST 106-2320-B-077-001-MY3
6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by the deposition of β-amyloid peptide (Aβ). There are currently no drugs that can successfully treat this disease. This study first explored the anti-inflammatory activity of seven components isolated from

Indexed as

Alzheimer DiseaseMaleimidesPlaque, AmyloidAmyloid beta-Protein PrecursorAnimalsCell LineMiceMice, TransgenicMicrogliaPolyporalesPresenilin-1Amyloid beta-Protein Precursorantrodin CAPP protein, mouseMaleimidesPresenilin-1presenilin 1, mouseAlzheimer’s diseaseamyloid plaqueantrodin CAPPswe/PS1dE9 transgenic miceEK100microgliaperivascular clearance

Identifiers

PMID34638752
PMCPMC8508921
OpenAlexW3203907284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.