Evidence map›Paper›PMID 34638691›Full record

ArticleInternational journal of molecular sciences2021

The MiR-320 Family Is Strongly Downregulated in Patients with COVID-19 Induced Severe Respiratory Failure.

Ruth P Duecker, Elisabeth H Adam, Sarah Wirtz, Lucia Gronau, Yascha Khodamoradi, Fabian J Eberhardt, Helena Donath, Desiree Gutmann, Maria J G T Vehreschild, Kai Zacharowski and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ruth P DueckerDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-1292-648X
Elisabeth H AdamDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy 2, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.ORCID 0000-0001-5008-6293
Sarah WirtzDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.
Lucia GronauDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.
Yascha KhodamoradiDepartment of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.ORCID 0000-0001-5972-0967
Fabian J EberhardtDepartment of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.
Helena DonathDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.
Desiree GutmannDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-5088-1366
Maria J G T VehreschildDepartment of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.
Kai ZacharowskiDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy 2, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.
Hermann KreyenbergDivision for Stem Cell Transplantation and Immunology, Department for Children and Adolescence, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.ORCID 0000-0003-3575-9175
Andreas G ChiocchettiDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-7329-9985
Stefan ZielenDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.
Ralf SchubertDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt am Main, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A high incidence of thromboembolic events associated with high mortality has been reported in severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infections with respiratory failure. The present study characterized post-transcriptional gene regulation by global microRNA (miRNA) expression in relation to activated coagulation and inflammation in 21 critically ill SARS-CoV-2 patients. The cohort consisted of patients with moderate respiratory failure (

Indexed as

AgedAged, 80 and overBlood CoagulationCOVID-19Disease ProgressionDown-RegulationFemaleHumansInflammationMaleMicroRNAsMiddle AgedRespiratory InsufficiencySARS-CoV-2Severity of Illness IndexMicroRNAsMIRN320 microRNA, humanCRPD-dimerlung diseasemiRNArespiratory failureSARS-CoV-2

Identifiers

PMID34638691
PMCPMC8508658

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.