Evidence map›Paper›PMID 34638650›Full record

ArticleInternational journal of molecular sciences2021

Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling.

Chen-Sheng Chen, Bo-Yi Pan, Ping-Hsuan Tsai, Fang-Yu Chen, Wen-Chin Yang, Ming-Yi Shen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. International journal of molecular sciences · 2025
    Article
  5. An Ingenane-Type Diterpene fromInternational journal of molecular sciences · 2024
    Article
  6. Review
  7. Anti-inflammatory therapy of atherosclerosis: focusing on IKKβ.Journal of inflammation (London, England) · 2023
    Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chen-Sheng ChenThe Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.ORCID 0000-0003-1466-4994
Bo-Yi PanGraduate Institute of Biomedical Sciences, China Medical University, 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.
Ping-Hsuan TsaiGraduate Institute of Biomedical Sciences, China Medical University, 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.ORCID 0000-0002-2548-4895
Fang-Yu ChenGraduate Institute of Biomedical Sciences, China Medical University, 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.
Wen-Chin YangAgricultural Biotechnology Research Center, Academia Sinica, 128, Sec. 2, Academia Rd., Nankang, Taipei 11529, Taiwan.ORCID 0000-0001-6410-2581
Ming-Yi ShenGraduate Institute of Biomedical Sciences, China Medical University, 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.ORCID 0000-0002-9351-1912
China Medical University · TWAgricultural Biotechnology Research Center, Academia Sinica · TWAsia University · TW

Funding

China Medical University CMU109-MF-70 and CMU110-MF-41China Medical University Hospital DMR-106-118, DMR-108-127, and DMR-109-142Ministry of Science and Technology of Taiwan MOST108-2320-B-039-034-MY3
6 · The paper itself

Abstract

Reactive oxygen species (ROS)-induced vascular endothelial cell apoptosis is strongly associated with atherosclerosis progression. Herein, we aimed to examine whether Kansuinine A (KA), extracted from

Indexed as

AnimalsAortaApolipoproteins EApoptosisAtherosclerosisCells, CulturedDiterpenesEndothelial CellsHumansHydrogen PeroxideI-kappa B KinaseMiceNF-kappa BNF-KappaB Inhibitor alphaOxidative StressReactive Oxygen SpeciesApolipoproteins EDiterpenesHydrogen PeroxideI-kappa B Kinasekansuinin ANF-kappa BNF-KappaB Inhibitor alphaReactive Oxygen Speciesanti-atherogenic drugatherosclerosishuman aortic endothelial cellsKansuinine Areactive oxygen species

Identifiers

PMID34638650
PMCPMC8508741
OpenAlexW3203109199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.