Evidence map›Paper›PMID 34638579›Full record

ArticleInternational journal of molecular sciences2021

Peiminine Reduces ARTS-Mediated Degradation of XIAP by Modulating the PINK1/Parkin Pathway to Ameliorate 6-Hydroxydopamine Toxicity and α-Synuclein Accumulation in Parkinson's Disease Models In Vivo and In Vitro.

Yu-Ling Hsu, Huey-Shan Hung, Chia-Wen Tsai, Shih-Ping Liu, Yu-Ting Chiang, Yun-Hua Kuo, Woei-Cherng Shyu, Shinn-Zong Lin, Ru-Huei Fu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Unraveling Molecular Targets for Neurodegenerative Diseases ThroughInternational journal of molecular sciences · 2025
    Review
  3. Article
  4. Neural Correlates and Molecular Mechanisms of Memory and Learning.International journal of molecular sciences · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Anti-Parkinson Effects ofMarine drugs · 2023
    Article
  13. Article
  14. Review
  15. Systematic Analysis Strategy Based on Network Pharmacology to Investigate the Potential Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yu-Ling HsuGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Huey-Shan HungGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Chia-Wen TsaiDepartment of Nutrition, China Medical University, Taichung 40402, Taiwan.
Shih-Ping LiuGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Yu-Ting ChiangGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Yun-Hua KuoDepartment of Nursing, Taipei Veterans General Hospital, Taipei 12217, Taiwan.
Woei-Cherng ShyuGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Shinn-Zong LinBioinnovation Center, Tzu Chi Foundation, Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien 970, Taiwan.
Ru-Huei FuGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
China Medical University · TWChina Medical University Hospital · TWTaipei Veterans General Hospital · TWTzu Chi Foundation · TW

Funding

China Medical University Hospital DMR106-076Ministry of Science and Technology, Taiwan MOST 108-2314-B-039-025-
6 · The paper itself

Abstract

Parkinson's disease (PD) is a degenerative disease that can cause motor, cognitive, and behavioral disorders. The treatment strategies being developed are based on the typical pathologic features of PD, including the death of dopaminergic (DA) neurons in the substantia nigra of the midbrain and the accumulation of α-synuclein in neurons. Peiminine (PMN) is an extract of

Indexed as

alpha-SynucleinAnimalsAnimals, Genetically ModifiedApoptosis Regulatory ProteinsCaenorhabditis elegansCaenorhabditis elegans ProteinsCevanesDopamineDopaminergic NeuronsNerve DegenerationParkinson DiseaseProteasome Endopeptidase ComplexProtein Serine-Threonine KinasesPTEN-Induced Putative KinaseSubstantia NigraUbiquitinalpha-SynucleinApoptosis Regulatory ProteinsCaenorhabditis elegans ProteinsCevanesDopamineparkin proteinpeimininepink-1 protein, C elegansProteasome Endopeptidase ComplexProtein Serine-Threonine KinasesPTEN-Induced Putative KinaseUbiquitinUbiquitin-Protein LigasesX-Linked Inhibitor of Apoptosis Protein6-hydroxydopamineapoptosisARTSautophagyparkinParkinson’s diseasepeiminineproteasomeXIAPα-synuclein

Identifiers

PMID34638579
PMCPMC8549710
OpenAlexW3199201703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.