Evidence map›Paper›PMID 34638569›Full record

ArticleInternational journal of molecular sciences2021

Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis.

Guangying Shao, Jinzhao He, Jia Meng, Ang Ma, Xiaoqiang Geng, Shun Zhang, Zhiwei Qiu, Dongmei Lin, Min Li, Hong Zhou and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 80 citations in OpenAlex.

  1. Review
  2. Article
  3. Anti-Inflammatory Potential ofPharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Guangying ShaoState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.ORCID 0000-0002-0255-5232
Jinzhao HeState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Jia MengState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Ang MaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Xiaoqiang GengState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Shun ZhangState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Zhiwei QiuState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Dongmei LinFuzhou Institute of Green Valley Bio-Pharm Technology, Fuzhou 350002, China.
Min LiState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Hong ZhouState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Shuqian LinFuzhou Institute of Green Valley Bio-Pharm Technology, Fuzhou 350002, China.
Baoxue YangState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.ORCID 0000-0002-7966-2095
Peking University · CNFujian Agriculture and Forestry University · CNMinistry of Education of the People's Republic of China · CN

Funding

Beijing Natural Science Foundation 7172113National Natural Science Foundation of China 81330074National Natural Science Foundation of China 81620108029National Natural Science Foundation of China 81974083
6 · The paper itself

Abstract

Renal ischemia reperfusion injury (RIRI) is one of the main causes of acute kidney injury (AKI), which can lead to acute renal failure. The development of RIRI is so complicated that it involves many factors such as inflammatory response, oxidative stress and cell apoptosis. Ganoderic acids (GAs), as one of the main pharmacological components of

Indexed as

Acute Kidney InjuryAnimalsApoptosisCell LineCyclooxygenase 2Disease Models, AnimalInflammationInterleukin-6MaleMiceMice, Inbred C57BLMyeloid Differentiation Factor 88NF-kappa BNitric Oxide Synthase Type IIOxidative StressProtective AgentsCyclooxygenase 2ganoderic acidInterleukin-6Myeloid Differentiation Factor 88NF-kappa BNitric Oxide Synthase Type IIProtective AgentsToll-Like Receptor 4Triterpenesacute kidney injurycell apoptosisganoderic acidshypoxia reoxygenationinflammationrenal ischemia reperfusion injury

Identifiers

PMID34638569
PMCPMC8508562
OpenAlexW3200793231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.