Evidence map›Paper›PMID 34638528›Full record

ArticleInternational journal of molecular sciences2021

Proteoglycan Combined with Hyaluronic Acid and Hydrolyzed Collagen Restores the Skin Barrier in Mild Atopic Dermatitis and Dry, Eczema-Prone Skin: A Pilot Study.

Young In Lee, Sang Gyu Lee, Jemin Kim, Sooyeon Choi, Inhee Jung, Ju Hee Lee

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Ameliorative effects ofMolecular medicine reports · 2026
    Article
  3. Hyaluronic Acid ProfhiloMedicina (Kaunas, Lithuania) · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. The Role of Collagens in Atopic Dermatitis.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Young In LeeDepartment of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID 0000-0001-6831-7379
Sang Gyu LeeDepartment of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Jemin KimDepartment of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID 0000-0001-6628-3507
Sooyeon ChoiDepartment of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Inhee JungGlobal Medical Research Center, Seoul 06526, Korea.
Ju Hee LeeDepartment of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Yonsei University · KRSeoul Medical Center · KR

Funding

Korea Mental Health Technology R&D Project, Ministry of Health & Welfare HP20C0171Yonsei University Faculty Research Grant 6-2020-0081
6 · The paper itself

Abstract

Dry and eczema-prone skin conditions such as atopic dermatitis and xerotic eczema primarily indicate an impaired skin barrier function, which leads to chronic pruritus. Here, we investigated the effects of a novel emollient containing H.ECM

Indexed as

Administration, TopicalAdultAnimalsAnti-Inflammatory AgentsCell LineCollagenDermatitis, AtopicEczemaEmollientsFemaleHumansHyaluronic AcidIchthyosisLiposomesMaleMiceAnti-Inflammatory AgentsCollagenEmollientsHyaluronic AcidLiposomesProteoglycansdry skineczemahydrationliposomeproteoglycanskin barrier

Identifiers

PMID34638528
PMCPMC8508667
OpenAlexW3199117589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.