Evidence map›Paper›PMID 34638496›Full record

ArticleCancers2021

Aberrant Expression of and Cell Death Induction by Engagement of the MHC-II Chaperone CD74 in Anaplastic Large Cell Lymphoma (ALCL).

Kathrin D Wurster, Mariantonia Costanza, Stephan Kreher, Selina Glaser, Björn Lamprecht, Nikolai Schleussner, Ioannis Anagnostopoulos, Michael Hummel, Korinna Jöhrens, Harald Stein and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 4 countries.

Kathrin D WursterMax-Delbrück-Center (MDC) for Molecular Medicine, 13125 Berlin, Germany.
Mariantonia CostanzaMax-Delbrück-Center (MDC) for Molecular Medicine, 13125 Berlin, Germany.
Stephan KreherMax-Delbrück-Center (MDC) for Molecular Medicine, 13125 Berlin, Germany.
Selina GlaserInstitute of Human Genetics, Ulm University, Ulm University Medical Center, 89081 Ulm, Germany.
Björn LamprechtMax-Delbrück-Center (MDC) for Molecular Medicine, 13125 Berlin, Germany.
Nikolai SchleussnerMax-Delbrück-Center (MDC) for Molecular Medicine, 13125 Berlin, Germany.
Ioannis AnagnostopoulosInstitute of Pathology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Michael HummelGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Korinna JöhrensInstitute of Pathology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Harald SteinPathodiagnostik Berlin, 12099 Berlin, Germany.
Arturo MolinaSutro Biopharma, South San Francisco, CA 94080, USA.
Arjan DiepstraDepartment of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0001-9239-1050
Bernd GillissenDepartment of Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Karl KöchertMax-Delbrück-Center (MDC) for Molecular Medicine, 13125 Berlin, Germany.ORCID 0000-0002-5548-2022
Reiner SiebertInstitute of Human Genetics, Ulm University, Ulm University Medical Center, 89081 Ulm, Germany.
Olaf MerkelUnit of Experimental and Laboratory Animal Pathology, Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria.
Lukas KennerUnit of Experimental and Laboratory Animal Pathology, Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-2184-1338
Martin JanzMax-Delbrück-Center (MDC) for Molecular Medicine, 13125 Berlin, Germany.
Stephan MathasMax-Delbrück-Center (MDC) for Molecular Medicine, 13125 Berlin, Germany.
Max Delbrück Center · DECharité - Universitätsmedizin Berlin · DEGerman Cancer Research Center · DEMedical University of Vienna · ATUniversität Ulm · DEPathodiagnostik Berlin · DESutro Biopharma (United States) · USUniversity Medical Center Groningen · NL

Funding

Berliner Krebsgesellschaft MAFF-2012-29Deutsche Forschungsgemeinschaft MA 3313/2-1 and JA 1847/2-1European Union´s Horizon 2020 Marie Sklodowska-Curie grant No 675712
6 · The paper itself

Abstract

In 50-60% of cases, systemic anaplastic large cell lymphoma (ALCL) is characterized by the t(2;5)(p23;q35) or one of its variants, considered to be causative for anaplastic lymphoma kinase (ALK)-positive (ALK

Indexed as

ALK translocationCD74invariant chainMHC-IIT cell lymphoma

Identifiers

PMID34638496
PMCPMC8507667
OpenAlexW3202920788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.