ReviewCancers2021
Back to the Future: Very High-Energy Electrons (VHEEs) and Their Potential Application in Radiation Therapy.
Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The evolution of FLASH radiotherapy: a bibliometric analysis.Frontiers in oncology · 2025Pooled it
- Structural and Functional Characteristics of the Liver After Fractionated Local Electron Irradiation and Against the Background of Ascorbic Acid Administration.Journal of personalized medicine · 2026Review
- Macro Monte Carlo dose calculation for very high energy electron (VHEE) radiotherapy.Medical physics · 2026Article
- Development and validation of a novel pulse optimization and beam control system for conventional and ultra high dose-per-pulse (FLASH) irradiation.Medical physics · 2026Article
- Start-to-end modelling of laser-plasma acceleration, beam transport and dose deposition of very high-energy electrons for radiotherapy.Scientific reports · 2026Article
- Article
- Emerging strategies in radiation therapy: promises and challenges of spatial fractionation, ultra-high dose rates, and nanoparticles.Journal of physics D: Applied physics · 2025Review
- Comparison of protons and very high-energy electrons transmission pencil-beam-scanning for FLASH radiotherapy.Physics and imaging in radiation oncology · 2025Article
- Clinical translation of ultra-high dose rate flash radiotherapy: Opportunities, challenges, and prospects.World journal of radiology · 2025Review
- Preparations for Ultra-High Dose Rate 25-90 MeV Electron Radiation Experiments with a Compact, High-Peak-Current, X-band Linear Accelerator.Radiation research · 2025Article
- Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review).Molecular and clinical oncology · 2025Review
- Consensus statement on the exploration of clinical translation and application of electron ultra-high dose rate FLASH radiotherapy.Precision radiation oncology · 2025Article
- Preclinical tumor control with a laser-accelerated high-energy electron radiotherapy prototype.Nature communications · 2025Article
- On the acceptance, commissioning, and quality assurance of electron FLASH units.Medical physics · 2025Article
- Review
- Implementation and validation of a very-high-energy electron model in the matRad treatment planning system.Medical physics · 2025Article
- Solid Cancer Treatment with Electric-Induced Field Emission Materials: A Hypothesis for Targeting Deep-Seated Tumors : Electric-Induced Field Emission Materials for Targeting Deep-Seated Tumors.Galen medical journal · 2025Article
- Comparative treatment planning of very high-energy electrons and photon volumetric modulated arc therapy: Optimising energy and beam parameters.Physics and imaging in radiation oncology · 2025Article
- Treatment planning for very high energy electrons: Studies that indicate the potential of the modality.Physics and imaging in radiation oncology · 2024Review
- Democratizing FLASH Radiotherapy.Seminars in radiation oncology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The development of innovative approaches that would reduce the sensitivity of healthy tissues to irradiation while maintaining the efficacy of the treatment on the tumor is of crucial importance for the progress of the efficacy of radiotherapy. Recent methodological developments and innovations, such as scanned beams, ultra-high dose rates, and very high-energy electrons, which may be simultaneously available on new accelerators, would allow for possible radiobiological advantages of very short pulses of ultra-high dose rate (FLASH) therapy for radiation therapy to be considered. In particular, very high-energy electron (VHEE) radiotherapy, in the energy range of 100 to 250 MeV, first proposed in the 2000s, would be particularly interesting both from a ballistic and biological point of view for the establishment of this new type of irradiation technique. In this review, we examine and summarize the current knowledge on VHEE radiotherapy and provide a synthesis of the studies that have been published on various experimental and simulation works. We will also consider the potential for VHEE therapy to be translated into clinical contexts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.