Evidence map›Paper›PMID 34638421›Full record

ArticleCancers2021

Prediction of Early Distant Recurrence in Upfront Resectable Pancreatic Adenocarcinoma: A Multidisciplinary, Machine Learning-Based Approach.

Diego Palumbo, Martina Mori, Francesco Prato, Stefano Crippa, Giulio Belfiori, Michele Reni, Junaid Mushtaq, Francesca Aleotti, Giorgia Guazzarotti, Roberta Cao and 8 more

Registry-linked trialAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05816954 (Artificial Intelligence-based Identification of Imaging Biomarkers of Lung FRAILty in Patients With Acute Respiratory Distress Syndrome.), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05816954 recruitingnot on this mapstarted 2023, after this paper: background citation

Artificial Intelligence-based Identification of Imaging Biomarkers of Lung FRAILty in Patients With Acute Respiratory Distress Syndrome.

TypeobservationalSponsorUniversità Vita-Salute San RaffaeleRan2023 to 2027Enrolled100ConditionsAcute Respiratory Distress Syndrome, BarotraumaArmsChest Computed Tomography Scan per normal clinical practice
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
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  6. Article
  7. Article
  8. Article
  9. Preoperative prediction of early recurrence in resectable pancreatic cancer integrating clinical, radiologic, and CT radiomics features.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Article
  10. Article
  11. Review
  12. Review
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  15. Review
  16. Pancreatic cancer, radiomics and artificial intelligence.The British journal of radiology · 2022
    Review
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Diego PalumboDepartment of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0002-7906-540X
Martina MoriDepartment of Medical Physics, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Francesco PratoSchool of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Stefano CrippaSchool of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Giulio BelfioriSchool of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Michele ReniSchool of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Junaid MushtaqDepartment of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Francesca AleottiSchool of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0001-7474-0325
Giorgia GuazzarottiDepartment of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Roberta CaoSchool of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Stephanie SteidlerDepartment of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Domenico TamburrinoPancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Emiliano SpeziSchool of Engineering, Cardiff University, Cardiff CF24 3AA, UK.
Antonella Del VecchioDepartment of Medical Physics, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0002-7889-7896
Stefano CascinuSchool of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Massimo FalconiSchool of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0001-9654-7243
Claudio FiorinoDepartment of Medical Physics, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Francesco De CobelliDepartment of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0003-4014-3711

Funding

Associazione Italiana per la Ricerca sul Cancro IG23015
6 · The paper itself

Abstract

Despite careful selection, the recurrence rate after upfront surgery for pancreatic adenocarcinoma can be very high. We aimed to construct and validate a model for the prediction of early distant recurrence (<12 months from index surgery) after upfront pancreaticoduodenectomy. After exclusions, 147 patients were retrospectively enrolled. Preoperative clinical and radiological (CT-based) data were systematically evaluated; moreover, 182 radiomics features (RFs) were extracted. Most significant RFs were selected using minimum redundancy, robustness against delineation uncertainty and an original machine learning bootstrap-based method. Patients were split into training (

Indexed as

computed tomographymachine learningpancreatic adenocarcinomaprognosisradiomicsX-ray

Identifiers

PMID34638421
PMCPMC8508250

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.