Evidence map›Paper›PMID 34638395›Full record

ReviewCancers2021

Transplant Oncology: An Evolving Field in Cancer Care.

Maen Abdelrahim, Abdullah Esmail, Ala Abudayyeh, Naoka Murakami, Ashish Saharia, Robert McMillan, David Victor, Sudha Kodali, Akshay Shetty, Joy V Nolte Fong and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
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  7. Ginkgolic acid inhibits CD8Journal of pharmaceutical analysis · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Maen AbdelrahimSection of GI Oncology, Department of Medical Oncology, Houston Methodist Cancer Center, Houston, TX 77030, USA.
Abdullah EsmailSection of GI Oncology, Department of Medical Oncology, Houston Methodist Cancer Center, Houston, TX 77030, USA.
Ala AbudayyehSection of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Naoka MurakamiDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8168-5811
Ashish SahariaDepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Robert McMillanDepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
David VictorDepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Sudha KodaliDepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Akshay ShettyDepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Joy V Nolte FongSherrie and Alan Conover Center for Liver Disease and Transplantation, JC Walter Jr. Center for Transplantation, Houston Methodist Hospital, Houston, TX 77030, USA.
Linda W MooreSherrie and Alan Conover Center for Liver Disease and Transplantation, JC Walter Jr. Center for Transplantation, Houston Methodist Hospital, Houston, TX 77030, USA.
Kirk HeyneSection of GI Oncology, Department of Medical Oncology, Houston Methodist Cancer Center, Houston, TX 77030, USA.
A Osama GaberDepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Rafik Mark GhobrialDepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Cornell University · USHouston Methodist · USMethodist Hospital · USBrigham and Women's Hospital · USThe University of Texas MD Anderson Cancer Center · US

Funding

Protection of kidney from autoimmunity by modulating co-stimlatory signalingK08DK120868 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI MURAKAMI, NAOKA · 2019 to 2023
$886k
NIDDK NIH HHS K08 DK120868
6 · The paper itself

Abstract

Transplant oncology is an emerging concept of cancer treatment with a promising prospective outcome. The application of oncology, transplant medicine, and surgery to improve patients' survival and quality of life is the core of transplant oncology. Hepatobiliary malignancies have been treated by liver transplantation (LT) with significant improved outcome. In addition, as the liver is the most common site of metastasis for colorectal cancer (CRC), patients with CRC who have stable unresectable liver metastases are good candidates for LT, and initial studies have shown improved survival compared to palliative systemic therapy. The indications of LT for hepatobiliary malignancies have been slowly expanded over the years in a stepwise manner; however, they have only been shown to improve patient survival in the setting of limited systemic therapy options. This review illustrates the concept and history of transplant oncology as an evolving field for the management of hepatocellular carcinoma, intrahepatic biliary cancer, and liver-only metastasis of non-hepatobiliary carcinoma. The utility of immunotherapy in the transplant setting is discussed as well as the feasibility of using circulating tumor DNA for surveillance post-transplantation.

Indexed as

cholangiocarcinomacirculating tumor DNAcolorectal cancershepatocellular carcinomaimmunotherapyliver metastasesliver transplantationneuroendocrine tumortransplant oncology

Identifiers

PMID34638395
PMCPMC8508383
OpenAlexW3203305712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.