Evidence map›Paper›PMID 34638343›Full record

ArticleCancers2021

Artificial Light at Night Reduces Anxiety-like Behavior in Female Mice with Exacerbated Mammary Tumor Growth.

William H Walker, Raegan M Kvadas, Laura E May, Jennifer A Liu, Jacob R Bumgarner, James C Walton, A Courtney DeVries, Robert T Dauchy, David E Blask, Randy J Nelson

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

William H WalkerDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26505, USA.ORCID 0000-0001-6209-5015
Raegan M KvadasDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26505, USA.
Laura E MayDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26505, USA.
Jennifer A LiuDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26505, USA.ORCID 0000-0002-2770-1320
Jacob R BumgarnerDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26505, USA.ORCID 0000-0002-0387-9263
James C WaltonDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26505, USA.ORCID 0000-0002-3049-1029
A Courtney DeVriesDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26505, USA.
Robert T DauchyDepartment of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
David E BlaskDepartment of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Randy J NelsonDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26505, USA.ORCID 0000-0002-8194-4016
West Virginia University · USTulane University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
Stroke and Alzheimers Disease Related DementiasT32AG052375 · NIA · WEST VIRGINIA UNIVERSITY · PI Paul D Chantler, BERNARD G. SCHREURS · 2017 to 2026
$3.5M
Adverse Consequences of Light at Night for Cerebral IschemiaR01NS092388 · NINDS · WEST VIRGINIA UNIVERSITY · PI DEVRIES, ANNE COURTNEY, NELSON, RANDY J. · 2015 to 2019
$2.3M
Affective Consequences of ChemotherapyR01CA194924 · NCI · WEST VIRGINIA UNIVERSITY · PI DEVRIES, ANNE COURTNEY · 2015 to 2019
$2.0M
NCI NIH HHS R01CA194924NIA NIH HHS T32 AG052375NIGMS NIH HHS U54GM104942-03NINDS NIH HHS R01NS092388
6 · The paper itself

Abstract

Artificial light at night (ALAN) is a pervasive phenomenon. Although initially assumed to be innocuous, recent research has demonstrated its deleterious effects on physiology and behavior. Exposure to ALAN is associated with disruptions to sleep/wake cycles, development of mood disorders, metabolic disorders, and cancer. However, the influence of ALAN on affective behavior in tumor-bearing mice has not been investigated. We hypothesize that exposure to ALAN accelerates mammary tumor growth and predict that ALAN exacerbates negative affective behaviors in tumor-bearing mice. Adult (>8 weeks) female C3H mice received a unilateral orthotropic injection of FM3A mouse mammary carcinoma cells (1.0 × 10

Indexed as

breast cancercircadian disruptioncircadian rhythmsdim light at nighttumor growth

Identifiers

PMID34638343
PMCPMC8508227
OpenAlexW3204726379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.