Evidence map›Paper›PMID 34638266›Full record

ArticleCancers2021

Microbe-Mediated Activation of Toll-like Receptor 2 Drives PDL1 Expression in HNSCC.

Jacqueline E Mann, Megan L Ludwig, Aditi Kulkarni, Erin B Scheftz, Isabel R Murray, Jingyi Zhai, Elizabeth Gensterblum-Miller, Hui Jiang, J Chad Brenner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Targeted lungScience advances · 2026
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  4. Review
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  7. Prognostic value of CD103Oral oncology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jacqueline E MannDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Megan L LudwigDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Aditi KulkarniDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Erin B ScheftzDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Isabel R MurrayDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Jingyi ZhaiDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Elizabeth Gensterblum-MillerDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8714-1257
Hui JiangDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-2718-9811
J Chad BrennerDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3238-1111
University of Michigan · US

Funding

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
NIGMS NIH HHS T32 GM007315NIH HHS F31-DE-027600-01NIH HHS P30-CA046592NIH HHS U01-DE025184
6 · The paper itself

Abstract

As immunotherapies targeting the PDL1 checkpoint have become a mainstay of treatment for a subset of head and neck squamous cell carcinoma (HNSCC) patients, a detailed understanding of the mechanisms underlying PDL1-mediated immune evasion is needed. To elucidate factors regulating expression of PDL1 in HNSCC cells, a genome-wide CRISPR profiling approach was implemented to identify genes and pathways conferring altered PDL1 expression in an HNSCC cell line model. Our screen nominated several candidate PDL1 drivers, including Toll-like Receptor 2 (TLR2). Depletion of TLR2 blocks interferon-γ-induced PDL1 expression, and stimulation of TLR2 with either

Indexed as

CRISPRHNSCCmicrobiomePDL1TLR2

Identifiers

PMID34638266
PMCPMC8508280
OpenAlexW3203747839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.