Evidence map›Paper›PMID 34638231›Full record

ArticleCancers2021

Disruption of miRNA-mRNA Networks Defines Novel Molecular Signatures for Penile Carcinogenesis.

Tatiane Katsue Furuya, Claudio Bovolenta Murta, Alexis Germán Murillo Carrasco, Miyuki Uno, Laura Sichero, Luisa Lina Villa, Leonardo Cardilli, Rafael Ferreira Coelho, Giuliano Betoni Guglielmetti, Mauricio Dener Cordeiro and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Exosomal ncRNAs in reproductive cancers†.Biology of reproduction · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Prostate Cancer Secretome and Membrane Proteome fromInternational journal of molecular sciences · 2022
    Article
  8. Article
  9. Upregulated miRNAs on theFrontiers in genetics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Tatiane Katsue FuruyaCenter for Translational Research in Oncology (LIM24), Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo CEP 01246-000, SP, Brazil.
Claudio Bovolenta MurtaDepartamento de Urologia, ICESP, HCFMUSP, Sao Paulo CEP 01246-000, SP, Brazil.ORCID 0000-0001-7813-7128
Alexis Germán Murillo CarrascoCenter for Translational Research in Oncology (LIM24), Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo CEP 01246-000, SP, Brazil.ORCID 0000-0002-7372-2608
Miyuki UnoCenter for Translational Research in Oncology (LIM24), Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo CEP 01246-000, SP, Brazil.
Laura SicheroCenter for Translational Research in Oncology (LIM24), Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo CEP 01246-000, SP, Brazil.ORCID 0000-0002-7999-5818
Luisa Lina VillaCenter for Translational Research in Oncology (LIM24), Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo CEP 01246-000, SP, Brazil.
Leonardo CardilliDepartamento de Patologia, ICESP, HCFMUSP, Sao Paulo CEP 01246-000, SP, Brazil.
Rafael Ferreira CoelhoDepartamento de Urologia, ICESP, HCFMUSP, Sao Paulo CEP 01246-000, SP, Brazil.
Giuliano Betoni GuglielmettiDepartamento de Urologia, ICESP, HCFMUSP, Sao Paulo CEP 01246-000, SP, Brazil.
Mauricio Dener CordeiroDepartamento de Urologia, ICESP, HCFMUSP, Sao Paulo CEP 01246-000, SP, Brazil.
Katia Ramos Moreira LeiteDepartamento de Urologia, ICESP, HCFMUSP, Sao Paulo CEP 01246-000, SP, Brazil.
William Carlos NahasDepartamento de Urologia, ICESP, HCFMUSP, Sao Paulo CEP 01246-000, SP, Brazil.
Roger ChammasCenter for Translational Research in Oncology (LIM24), Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo CEP 01246-000, SP, Brazil.ORCID 0000-0003-0342-8726
José PontesDepartamento de Urologia, ICESP, HCFMUSP, Sao Paulo CEP 01246-000, SP, Brazil.
Instituto do Câncer do Estado de São Paulo · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/17097-2
6 · The paper itself

Abstract

Penile cancer (PeC) carcinogenesis is not fully understood, and no biomarkers are reported in clinical practice. We aimed to investigate molecular signatures based on miRNA and mRNA and perform an integrative analysis to identify molecular drivers and pathways for PeC development. Affymetrix miRNA microarray was used to identify differentially expressed miRNAs (DEmiRs) comparing 11 tumoral tissues (TT) paired with non-neoplastic tissues (NNT) with further validation in an independent cohort (

Indexed as

carcinogenesisgene expression levelsintegrative analysismiRNApenile cancer

Identifiers

PMID34638231
PMCPMC8507530
OpenAlexW3200944337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.