Evidence map›Paper›PMID 34638230›Full record

ArticleCancers2021

Increased Plasma Levels of lncRNAs

Sebastian Fantini, Sebastiano Rontauroli, Stefano Sartini, Margherita Mirabile, Elisa Bianchi, Filippo Badii, Monica Maccaferri, Paola Guglielmelli, Tiziana Ottone, Raffaele Palmieri and 22 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Plasma expression of long non-coding RNAFrontiers in oncology · 2026
    Article
  3. Prognostic and Predictive Models in Myelofibrosis.Current hematologic malignancy reports · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 8 institutions in 1 country.

Sebastian FantiniCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Sebastiano RontauroliCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Stefano SartiniCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Margherita MirabileCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Elisa BianchiCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-6110-5944
Filippo BadiiCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Monica MaccaferriDepartment of Laboratory Medicine and Pathology, Diagnostic Hematology and Clinical Genomics, AUSL/AOU Policlinico, 41124 Modena, Italy.ORCID 0000-0002-8874-747X
Paola GuglielmelliDepartment of Experimental and Clinical Medicine, and Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), University of Florence, Careggi University Hospital, 50134 Florence, Italy.
Tiziana OttoneDepartment of Biomedicine and Prevention, University of Tor Vergata, 00133 Rome, Italy.
Raffaele PalmieriDepartment of Biomedicine and Prevention, University of Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-2855-8121
Elena GenoveseCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Chiara CarrettaCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0001-5952-0818
Sandra ParentiCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Selene MalliaCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Lara TavernariCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Costanza SalvadoriDepartment of Experimental and Clinical Medicine, and Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), University of Florence, Careggi University Hospital, 50134 Florence, Italy.
Francesca GesulloDepartment of Experimental and Clinical Medicine, and Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), University of Florence, Careggi University Hospital, 50134 Florence, Italy.
Chiara MaccariDepartment of Experimental and Clinical Medicine, and Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), University of Florence, Careggi University Hospital, 50134 Florence, Italy.
Michela ZizzaDepartment of Experimental and Clinical Medicine, and Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), University of Florence, Careggi University Hospital, 50134 Florence, Italy.
Alexis GrandeDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Silvia SalmoiraghiHematology, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
Barbara MoraDivision of Hematology, Ospedale ASST Sette Laghi, University of Insubria, 21100 Varese, Italy.
Leonardo PotenzaDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, 41124 Modena, Italy.
Vittorio RostiCenter for the Study of Myelofibrosis, Foundation Policlinico San Matteo, Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.), 27100 Pavia, Italy.
Francesco PassamontiDivision of Hematology, Ospedale ASST Sette Laghi, University of Insubria, 21100 Varese, Italy.
Alessandro RambaldiHematology, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
Maria Teresa VosoDepartment of Biomedicine and Prevention, University of Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-6164-4761
Cristina MecucciDepartment of Medicine and Surgery, Section of Hematology and Clinical Immunology, University of Perugia, 06129 Perugia, Italy.
Enrico TagliaficoDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, 41124 Modena, Italy.ORCID 0000-0003-0981-2542
Mario LuppiDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, 41124 Modena, Italy.
Alessandro Maria VannucchiDepartment of Experimental and Clinical Medicine, and Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), University of Florence, Careggi University Hospital, 50134 Florence, Italy.
Rossella ManfrediniCentre for Regenerative Medicine, Life Sciences Department, University of Modena and Reggio Emilia, 41125 Modena, Italy.
University of Modena and Reggio Emilia · ITUniversity of Florence · ITUniversity of Rome Tor Vergata · ITOspedale Papa Giovanni XXIII · ITUniversity of Insubria · ITAzienda Ospedaliero-Universitaria di Modena · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Perugia · IT

Funding

Associazione Italiana per la Ricerca sul Cancro 21267 and 19818Ministero della Salute RF-2016-02362930Ministero dell'Istruzione, dell'Università e della Ricerca 2017WXR7ZT_005
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) have been recently described as key mediators in the development of hematological malignancies. In the last years, circulating lncRNAs have been proposed as a new class of non-invasive biomarkers for cancer diagnosis and prognosis and to predict treatment response. The present study is aimed to investigate the potential of circulating lncRNAs as non-invasive prognostic biomarkers in myelofibrosis (MF), the most severe among Philadelphia-negative myeloproliferative neoplasms. We detected increased levels of seven circulating lncRNAs in plasma samples of MF patients (

Indexed as

biomarkerslncRNAsMPNmyelofibrosisprognosis

Identifiers

PMID34638230
PMCPMC8507546
OpenAlexW3203333755

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.