Evidence map›Paper›PMID 34638000›Full record

ArticleNeurobiology of aging2022

Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.

Antoine Hone-Blanchet, Anastasia Bohsali, Lisa C Krishnamurthy, Salman Shahid, Qixiang Lin, Liping Zhao, David Loring, Felicia Goldstein, Samantha E John, Candace C Fleischer and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Neurobiology of aging · 2026
    Article
  4. Article
  5. Insulin-stimulated brain glucose uptake correlates with brain metabolites in severe obesity: A combined neuroimaging study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Antoine Hone-BlanchetDepartment of Neurology, School of Medicine, Emory University, Atlanta, Georgia. Electronic address: antoine.hone-blanchet@emory.edu.
Anastasia BohsaliDepartment of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
Lisa C KrishnamurthyDepartment of Physics & Astronomy, Georgia State University, Atlanta, Georgia; Center for Visual and Neurocognitive Rehabilitation, VA Medical Center, Decatur, Georgia.
Salman ShahidDepartment of Neurology, School of Medicine, Emory University, Atlanta, Georgia; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indianapolis.
Qixiang LinDepartment of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
Liping ZhaoDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia.
David LoringDepartment of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
Felicia GoldsteinDepartment of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
Samantha E JohnDepartment of Brain Health, Population Health & Health Equity Initiative, University of Nevada, Las Vegas, Nevada.
Candace C FleischerDepartment of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, Georgia; Department of Joint Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia.
Allan LeveyDepartment of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
James LahDepartment of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
Deqiang QiuDepartment of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, Georgia; Department of Joint Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia.
Bruce CrossonDepartment of Neurology, School of Medicine, Emory University, Atlanta, Georgia; Center for Visual and Neurocognitive Rehabilitation, VA Medical Center, Decatur, Georgia; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, Georgia.

Funding

The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's DiseaseR01AG070937 · NIA · EMORY UNIVERSITY · PI LAH, JAMES J · 2021 to 2025
$35.2M
Neural Mechanisms Underlying Compensation in DyslexiaR01HD096261 · NICHD · UNIVERSITY OF CONNECTICUT STORRS · PI HOEFT, FUMIKO · 2018 to 2023
$3.4M
Effects of Acute Exercise on Functional Magnetic Resonance Spectroscopy Measures of GABA in Aging and Chronic StrokeI21RX003581 · VA · VETERANS HEALTH ADMINISTRATION · PI KRISHNAMURTHY, LISA C. · 2021 to 2022
–
Beyond lesion-language mapping in aphasia: A novel imaging-based prediction modelIK1RX002629 · VA · VETERANS HEALTH ADMINISTRATION · PI KRISHNAMURTHY, LISA C. · 2019 to 2021
–
NIA NIH HHS R01 AG070937NICHD NIH HHS R01 HD096261RRD VA I21 RX003581RRD VA IK1 RX002629
6 · The paper itself

Abstract

Elevated expression of β-amyloid (Aβ

Indexed as

CognitionAgingAlzheimer DiseaseAmyloid beta-PeptidesAspartic AcidBiomarkersCreatineFemaleFrontal Lobegamma-Aminobutyric AcidHumansInositolMagnetic Resonance SpectroscopyMalePeptide Fragmentstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)Aspartic AcidBiomarkersCreatinegamma-Aminobutyric AcidInositolN-acetylaspartatePeptide Fragmentstau ProteinsAgingAlzheimer's diseaseCerebrospinal fluid biomarkersFrontal cortexGeneral cognitionMagnetic resonance spectroscopy

Identifiers

PMID34638000
PMCPMC9768839

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.