Evidence map›Paper›PMID 34637905›Full record

ArticleNeuroImage2021

Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution.

Loreen Ruhm, Nikolai Avdievich, Theresia Ziegs, Armin M Nagel, Henk M De Feyter, Robin A de Graaf, Anke Henning

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
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  19. In vivoMagnetic resonance in medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Loreen RuhmHigh-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany; IMPRS for Cognitive and Systems Neuroscience, Eberhard-Karls University of Tübingen, Germany. Electronic address: Loreen.ruhm@tuebingen.mpg.de.
Nikolai AvdievichHigh-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Theresia ZiegsHigh-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany; IMPRS for Cognitive and Systems Neuroscience, Eberhard-Karls University of Tübingen, Germany.
Armin M NagelInstitute of Radiology, University Hospital Erlangen, Erlangen, Germany; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Henk M De FeyterRadiology and Biomedical Imaging, Yale University, New Haven, CT, United States.
Robin A de GraafRadiology and Biomedical Imaging, Yale University, New Haven, CT, United States.
Anke HenningHigh-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany; Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas/Texas, United States.
University of Tübingen · DEYale University · USMax Planck Institute for Biological Cybernetics · DEThe University of Texas Southwestern Medical Center · USUniversitätsklinikum Erlangen · DE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Deuterium metabolic imaging (DMI) of neurological diseaseR01EB025840 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF, Henk De Feyter · 2019 to 2026
$4.2M
NCATS NIH HHS UL1 TR001863NIBIB NIH HHS R01 EB025840
6 · The paper itself

Abstract

purposeTo present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B

methodsThe study was performed with a double-tuned coil with 10 TxRx channels for

resultsThe metabolism of [6,6'-

conclusionX-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.

Indexed as

BrainDeuteriumGlucoseGray MatterHumansMagnetic Resonance ImagingDeuteriumGlucose9.4 TeslaDeuteriumDMIHuman brainOral glucose administrationTCA cycle

Identifiers

PMID34637905
PMCPMC8591372
OpenAlexW3207140528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.