ArticleNeuroImage2021
Functional connectome reorganization relates to post-stroke motor recovery and structural and functional disconnection.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07584681 (Connectomic Alterations Following Acute Ischemic Stroke in the Middle Cerebral Artery Territory), which is not on this map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Connectomic Alterations Following Acute Ischemic Stroke in the Middle Cerebral Artery Territory: A Pilot Study of Prognostic Value and Structural Disruption
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review of alterations in sensorimotor networks following stroke: implications for integration and functional outcomes across recovery stages.Frontiers in neurology · 2025Pooled it
- The Role of the Human Cerebellum for Learning from and Processing of External Feedback in Non-Motor Learning: A Systematic Review.Cerebellum (London, England) · 2024Pooled it
- The effects of rTMS on motor recovery after stroke: a systematic review of fMRI studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Early effect of thrombolysis on structural brain network organisation after anterior-circulation stroke in the randomized WAKE-UP trial.Human brain mapping · 2022Trial
- Electroacupuncture improves upper-limb motor function and modulates sensorimotor network connectivity in subacute stroke: a randomized controlled trial.Frontiers in neurologyTrial
- Structure-Function Decoupling Across Cerebrovascular Diseases: A Convergent Network Phenotype Requiring Disease-Specific Interpretation.CNS neuroscience & therapeutics · 2026Article
- Longitudinal alterations in static and dynamic functional connectivity in basal ganglia ischaemic stroke: implications for neurological recovery.Neuroradiology · 2026Article
- Structural connectome changes as biomarkers of stroke recovery: a longitudinal 7T MRI study.BMC neuroscience · 2026Article
- Stroke and motor outcomes are associated with regional and age-specific changes in periodic and aperiodic cortical activity.Experimental physiology · 2026Article
- The Cerebellar Connectome Disruptions in Ischemic Stroke.CNS neuroscience & therapeutics · 2026Article
- MEP-Guided Scalp Acupuncture Combined with Repetitive Transcranial Magnetic Stimulation for Post-Stroke Upper Extremity Motor Impairment: A Randomized Controlled Study Protocol.International journal of general medicine · 2026Article
- Krakencoder: a unified brain connectome translation and fusion tool.Nature methods · 2025Article
- A deep-learning model for predicting post-stroke cognitive impairment based on brain network damage.Quantitative imaging in medicine and surgery · 2025Article
- Alterations of static and dynamic changes in intrinsic brain activity and its relation to behavioral outcomes in subcortical ischemic stroke after one-month intervention.Scientific reports · 2025Article
- Reward Decision Network Disconnection in Poststroke Apathy: A Prospective Multimodality Imaging Study.Human brain mapping · 2025Article
- Predicting upper limb motor dysfunction after ischemic stroke: a functional near-infrared spectroscopy-based nomogram model.Frontiers in neurology · 2025Article
- Disconnection syndromes and injury to neural systems after ischemic stroke.Frontiers in stroke · 2025Article
- Important role of the right hemisphere in post-stroke cognitive impairment: a functional near-infrared spectroscopy study.Neurophotonics · 2025Article
- Brain repair mechanisms after cell therapy for stroke.Brain : a journal of neurology · 2024Review
- Context-dependent reduction in corticomuscular coupling for balance control in chronic stroke survivors.Experimental brain research · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Motor recovery following ischemic stroke is contingent on the ability of surviving brain networks to compensate for damaged tissue. In rodent models, sensory and motor cortical representations have been shown to remap onto intact tissue around the lesion site, but remapping to more distal sites (e.g. in the contralesional hemisphere) has also been observed. Resting state functional connectivity (FC) analysis has been employed to study compensatory network adaptations in humans, but mechanisms and time course of motor recovery are not well understood. Here, we examine longitudinal FC in 23 first-episode ischemic pontine stroke patients and utilize a graph matching approach to identify patterns of functional connectivity reorganization during recovery. We quantified functional reorganization between several intervals ranging from 1 week to 6 months following stroke, and demonstrated that the areas that undergo functional reorganization most frequently are in cerebellar/subcortical networks. Brain regions with more structural and functional connectome disruption due to the stroke also had more remapping over time. Finally, we show that functional reorganization is correlated with the extent of motor recovery in the early to late subacute phases, and furthermore, individuals with greater baseline motor impairment demonstrate more extensive early subacute functional reorganization (from one to two weeks post-stroke) and this reorganization correlates with better motor recovery at 6 months. Taken together, these results suggest that our graph matching approach can quantify recovery-relevant, whole-brain functional connectivity network reorganization after stroke.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.