Evidence map›Paper›PMID 34637751›Full record

ArticleCurrent biology : CB2021

Nigrostriatal dopamine signals sequence-specific action-outcome prediction errors.

Nick G Hollon, Elora W Williams, Christopher D Howard, Hao Li, Tavish I Traut, Xin Jin

Abstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  18. A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nick G HollonMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Elora W WilliamsMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Christopher D HowardMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Hao LiMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Tavish I TrautMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Xin JinMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Center for Motor Control and Disease, Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China; NYU-ECNU Institute of Brain and Cognitive Science, New York University Shanghai, Shanghai 200062, China. Electronic address: xjin@bio.ecnu.edu.cn.

Funding

Physiology and function of basal ganglia subcircuits in sequence learningR01NS083815 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI LEE, KUO-FEN · 2013 to 2022
$3.8M
Stress effects on circuitry regulating nigrostriatal dopamine during goal-directed actionK99MH119312 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI HOLLON, NICK GARBER · 2019 to 2021
$212k
NIMH NIH HHS K99 MH119312NINDS NIH HHS R01 NS083815
6 · The paper itself

Abstract

Dopamine has been suggested to encode cue-reward prediction errors during Pavlovian conditioning, signaling discrepancies between actual versus expected reward predicted by the cues.

Indexed as

DopamineRewardAnimalsConditioning, ClassicalCuesMiceReinforcement, PsychologyDopamineaction-outcomeaction sequenceefference copynigrostriatal dopamineprediction error

Identifiers

PMID34637751
PMCPMC8665080

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.