ArticleCurrent biology : CB2021
Functional architecture of neural circuits for leg proprioception in Drosophila.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Centralized brain networks controlling antennal grooming coordination.Nature communications · 2026Article
- Proprioceptive limit detectors contribute to sensorimotor control of the Drosophila leg.Nature communications · 2026Article
- Inhibitory circuits control leg movements duringeLife · 2026Article
- Article
- Inhibitory circuits control leg movements duringbioRxiv : the preprint server for biology · 2025Article
- An essential experimental control for functional connectivity mapping with optogenetics.Genetics · 2025Article
- Article
- Sensory Feedback and the Dynamic Control of Movement.Annual review of neuroscience · 2025Review
- Divergent neural circuits for proprioceptive and exteroceptive sensing of the Drosophila leg.Nature communications · 2025Article
- Miniature linear and split-belt treadmills reveal mechanisms of adaptive motor control in walking Drosophila.Current biology : CB · 2024Article
- Article
- Presynaptic inhibition selectively suppresses leg proprioception in behavingbioRxiv : the preprint server for biology · 2024Article
- A missense mutation in human INSC causes peripheral neuropathy.EMBO molecular medicine · 2024Article
- Organization of an ascending circuit that conveys flight motor state in Drosophila.Current biology : CB · 2024Article
- Biomechanical origins of proprioceptor feature selectivity and topographic maps in the Drosophila leg.Neuron · 2023Article
- Ascending neurons convey behavioral state to integrative sensory and action selection brain regions.Nature neuroscience · 2023Article
- Distinctive features of the central synaptic organization ofFrontiers in neural circuits · 2023Article
- The two-body problem: Proprioception and motor control across the metamorphic divide.Current opinion in neurobiology · 2022Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
To effectively control their bodies, animals rely on feedback from proprioceptive mechanosensory neurons. In the Drosophila leg, different proprioceptor subtypes monitor joint position, movement direction, and vibration. Here, we investigate how these diverse sensory signals are integrated by central proprioceptive circuits. We find that signals for leg joint position and directional movement converge in second-order neurons, revealing pathways for local feedback control of leg posture. Distinct populations of second-order neurons integrate tibia vibration signals across pairs of legs, suggesting a role in detecting external substrate vibration. In each pathway, the flow of sensory information is dynamically gated and sculpted by inhibition. Overall, our results reveal parallel pathways for processing of internal and external mechanosensory signals, which we propose mediate feedback control of leg movement and vibration sensing, respectively. The existence of a functional connectivity map also provides a resource for interpreting connectomic reconstruction of neural circuits for leg proprioception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.