ArticleCell2021
Mechanoreceptor synapses in the brainstem shape the central representation of touch.
Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
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- Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.bioRxiv : the preprint server for biology · 2025Article
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- The dorsal column nuclei encode and transmit the network signatures of mechanical allodynia.Cell reports · 2025Article
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- Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse's hand.eLife · 2025Article
- Trauma and Sensory Systems: Biological Mechanisms Involving the Skin and the 17q21 Gene Cluster.Biological psychiatry · 2025Review
- The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states.Cell reports · 2025Article
- Spinal sensory innervation of the intestine.Current opinion in neurobiology · 2025Review
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- Emergence of a brainstem somatosensory tonotopic map for substrate vibration.Nature neuroscience · 2025Article
- Non-invasive therapeutics for neurotrauma: a mechanistic overview.Frontiers in neurology · 2025Review
- C-LTMRs evoke wet dog shakes via the spinoparabrachial pathway.Science (New York, N.Y.) · 2024Article
- Regional Differences in Itch Transmission.The Journal of investigative dermatology · 2024Article
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- Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.Nature communications · 2024Article
- Sensory Input, Sex, and Function Shape Hypothalamic Cell Type Development.bioRxiv : the preprint server for biology · 2024Article
- Skin-type-dependent development of murine mechanosensory neurons.Developmental cell · 2023Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Mammals use glabrous (hairless) skin of their hands and feet to navigate and manipulate their environment. Cortical maps of the body surface across species contain disproportionately large numbers of neurons dedicated to glabrous skin sensation, in part reflecting a higher density of mechanoreceptors that innervate these skin regions. Here, we find that disproportionate representation of glabrous skin emerges over postnatal development at the first synapse between peripheral mechanoreceptors and their central targets in the brainstem. Mechanoreceptor synapses undergo developmental refinement that depends on proximity of their terminals to glabrous skin, such that those innervating glabrous skin make synaptic connections that expand their central representation. In mice incapable of sensing gentle touch, mechanoreceptors innervating glabrous skin still make more powerful synapses in the brainstem. We propose that the skin region a mechanoreceptor innervates controls the developmental refinement of its central synapses to shape the representation of touch in the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.