Evidence map›Paper›PMID 34637643›Full record

ArticleJournal of the Royal Society, Interface2021

Simulations reveal that different responses to cell crowding determine the expansion of

Vasiliki Kostiou, Michael W J Hall, Philip H Jones, Benjamin A Hall

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Vasiliki KostiouDepartment of medical physics and biomedical engineering, UCL, Gower Street, London WC1E 6BT, UK.
Michael W J HallMRC Cancer Unit, University of Cambridge, Hutchison-MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK.ORCID 0000-0003-2904-6902
Philip H JonesMRC Cancer Unit, University of Cambridge, Hutchison-MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK.
Benjamin A HallDepartment of medical physics and biomedical engineering, UCL, Gower Street, London WC1E 6BT, UK.ORCID 0000-0003-0355-2946
University College London · GBUniversity of Cambridge · GB

Funding

Cancer Research UK 17257Cancer Research UK C609/A17257Cancer Research UK C609/A27326Medical Research Council MC_UU_12022/9Medical Research Council MR/S000216/1Medical Research Council MR/S000216/2Wellcome Trust
6 · The paper itself

Abstract

During ageing, normal epithelial tissues progressively accumulate clones carrying mutations that increase mutant cell fitness above that of wild-type cells. Such mutants spread widely through the tissues, yet despite this cellular homeostasis and functional integrity of the epithelia are maintained. Two of the genes most commonly mutated in human skin and oesophagus are

Indexed as

EpitheliumReceptor, Notch1Tumor Suppressor Protein p53AnimalsCarcinoma, Squamous CellClone CellsMiceMutationNotch1 protein, mouseReceptor, Notch1Tumor Suppressor Protein p53cell competitionclonal evolutionepithelial dynamicssomatic mutationspatial modelling

Identifiers

PMID34637643
PMCPMC8510697
OpenAlexW3206438361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.