ArticleAlimentary pharmacology & therapeutics2021
Clinicopathological characteristics of early onset colorectal cancer.
Article in Alimentary pharmacology & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 39 citations in OpenAlex.
- Geographic and Ethnic Variation in Early-onset Colorectal Cancer: A Contemporary Scoping Review of Epidemiologic, Molecular, and Survival Patterns.Journal of gastrointestinal cancer · 2026Article
- Young-onset signet ring cell colorectal adenocarcinoma: demographics, clinicopathological profile, and survival analysis.Proceedings (Baylor University. Medical Center) · 2026Article
- Interpreting Early-Onset Colorectal Cancer in Japan: A Descriptive Epidemiologic Review Using Public Summary Statistics.Cancer science · 2026Review
- Safety of fruquintinib mono- and combo therapy in metastatic colorectal cancer: real-world subgroup analysis from China.Future oncology (London, England) · 2026Article
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- Trends and projections in cause-specific mortality among patients with colorectal cancer in the United States, 1999-2040.Frontiers in public health · 2026Article
- Article
- Early- vs. late-onset colon cancer: clinicopathological insights and survival outcomes in an East Asian cohort.International journal of colorectal disease · 2025Observational
- Young-onset versus late-onset colorectal cancer: clinicopathological features and survival outcome: a decade-long analysis from a middle Eastern tertiary center.World journal of surgical oncology · 2025Article
- Early-onset gastrointestinal cancers: comprehensive review and future directions.The British journal of surgery · 2025Review
- Survival analysis and prediction of early-onset colorectal cancer patients post-chemotherapy: an analysis based on the SEER database.International journal of colorectal disease · 2025Article
- Prognostic Differences Between Early-Onset and Late-Onset Colorectal Cancer.Medicina (Kaunas, Lithuania) · 2025Article
- Peripheral myelin protein 2 is underexpressed in early-onset colorectal cancer and inhibits metastasis.Frontiers in molecular biosciences · 2025Article
- Clinical and pathological characteristics of patients with colorectal cancer under age stratification.Frontiers in oncology · 2025Article
- Safety of fruquintinib in Chinese patients with colorectal cancer: an age subgroup analysis from a phase IV real-world clinical practice study.Therapeutic advances in medical oncology · 2025Article
- Predictive value of composite nutritional indicators geriatric nutritional risk index and controlling nutritional status for mortality risk in early-onset cancer survivors.Frontiers in nutrition · 2025Article
- Is early-onset colorectal cancer an evolving pandemic? Real-world data from a tertiary cancer center.The oncologist · 2024Article
- Temporal Trends in Racial and Gender Disparities of Early Onset Colorectal Cancer in the United States: An Analysis of the CDC WONDER Database.Journal of gastrointestinal cancer · 2024Review
- Global burden and cross-country health inequalities of early-onset colorectal cancer and its risk factors from 1990 to 2021 and its projection until 2036.BMC public health · 2024Article
- Western lifestyle, metaflammation and the cell of origin of colon cancer.Nature reviews. Gastroenterology & hepatology · 2024Article
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5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rising incidence of early onset colorectal cancer (EOCRC) might reflect a novel tumour entity.
aimsTo evaluate clinicopathological characteristics of sporadic EOCRC (in patients < 50 years old) and investigate changes over time
methodsAll patients with sporadic EOCRC between 1989 and 2016 were included and divided by age: 20-29 years (group I), 30-39 years (group II) and 40-49 years (group III).
resultsWe included 6400 patients. The presence of signet-ring cells and more poorly differentiated tumours were more common in the younger age groups: 5.4% and 3.7% for signet-ring cells in group I and II vs 1.4% in group III (P < 0.01), and 28.5% and 20.3% for poorly differentiated in group I and II vs 16.6% in group III, (P < 0.01 group I; P = 0.07 group II). Positive lymph nodes were more frequently observed in the younger age groups: 16.2% in group I vs 9.3% in group II (P = 0.01) and 7.9% (P < 0.01) in group III. Over time, a greater proportion of CRCs were diagnosed in women in group I (34.5% < 2004 vs 54.9%>2005, P = 0.09), and a higher percentage of rectal cancer was found in age group III (34.3% < 2004 vs 40.7% > 2005, P < 0.01). Mean overall survival was 6.3 years and improved over time.
conclusionsEOCRC is not only characterised by age of onset but also by the more frequent presence of signet-ring cells, more poorly differentiated tumours, and higher risk of lymph node metastases. In the most recent years, a higher proportion of rectal cancer was found from the age of 30 years, and a higher proportion of CRCs were diagnosed in females below the age of 30 years.
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