Evidence map›Paper›PMID 34637370›Full record

ArticleAnnals of medicine2021

Enterococcal bloodstream infections in critically ill patients with COVID-19: a case series.

Daniele Roberto Giacobbe, Laura Labate, Stefania Tutino, Federico Baldi, Chiara Russo, Chiara Robba, Lorenzo Ball, Silvia Dettori, Anna Marchese, Chiara Dentone and 9 more

Open access · goldAbstract read
In one paragraph

Article in Annals of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

  1. Gut microbial allies and adversaries in SARS-CoV-2 infection.Current research in microbial sciences · 2026
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  10. The Impact ofPathogens (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 2 countries.

Daniele Roberto GiacobbeDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Laura LabateDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Stefania TutinoDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Federico BaldiDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Chiara RussoDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Chiara RobbaDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Lorenzo BallDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Silvia DettoriDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Anna MarcheseDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Chiara DentoneClinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS for Oncology and Neurosciences, Genoa, Italy.
Laura MagnascoClinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS for Oncology and Neurosciences, Genoa, Italy.
Francesca CreaMicrobiology Unit, San Martino Policlinico Hospital - IRCCS for Oncology and Neurosciences, Genoa, Italy.
Edward WillisonMicrobiology Unit, San Martino Policlinico Hospital - IRCCS for Oncology and Neurosciences, Genoa, Italy.
Federica BrianoDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Denise BattagliniAnaesthesia and Intensive Care, San Martino Policlinico Hospital - IRCCS for Oncology and Neurosciences, Genoa, Italy.
Nicolò PatronitiDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Iole BrunettiAnaesthesia and Intensive Care, San Martino Policlinico Hospital - IRCCS for Oncology and Neurosciences, Genoa, Italy.
Paolo PelosiDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Matteo BassettiDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.ORCID 0000-0002-0145-9740
Ospedale Policlinico San Martino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn unexpected high prevalence of enterococcal bloodstream infection (BSI) has been observed in critically ill patients with COVID-19 in the intensive care unit (ICU). MATERIALS AND

methodsThe primary objective was to describe the characteristics of ICU-acquired enterococcal BSI in critically ill patients with COVID-19. A secondary objective was to exploratorily assess the predictors of 30-day mortality in critically ill COVID-19 patients with ICU-acquired enterococcal BSI.

resultsDuring the study period, 223 patients with COVID-19 were admitted to COVID-19-dedicated ICUs in our centre. Overall, 51 episodes of enterococcal BSI, occurring in 43 patients, were registered. 29 (56.9%) and 22 (43.1%) BSI were caused by

conclusionsThe cumulative incidence of enterococcal BSI is high in critically ill patients with COVID-19. Our results suggest a crucial role of the severity of the acute clinical conditions, to which both the underlying viral pneumonia and the enterococcal BSI may contribute, in majorly influencing the outcome.KEY MESSAGESThe cumulative incidence of enterococcal BSI is high in critically ill patients with COVID-19.The crude 30-day mortality of enterococcal BSI in critically ill patients with COVID-19 may be higher than 40%.There could be a crucial role of the severity of the acute clinical conditions, to which both the underlying viral pneumonia and the enterococcal BSI may contribute, in majorly influencing the outcome.

Indexed as

Enterococcus faecalisEnterococcus faeciumMortalityVancomycin-Resistant EnterococciAgedBacteremiaCOVID-19Critical IllnessCross InfectionFemaleGram-Positive Bacterial InfectionsHumansIntensive Care UnitsMaleMicrobial Sensitivity TestsMiddle AgedBSICOVID-19EnterococcusSARS-CoV-2VRE

Identifiers

PMID34637370
PMCPMC8519517
OpenAlexW3205463695

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.