SynthesisOdontology2022
Virucidal efficacy of chlorhexidine: a systematic review.
Synthesis in Odontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06077032 (Chlorhexidine and Garlic Extract as Potential Topical Virucidal Therapeutic Agents of Non-Genital Warts), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chlorhexidine and Garlic Extract as Potential Topical Virucidal Therapeutic Agents of Non-Genital Warts: A Prospective, Randomized, Controlled, Blinded Clinical Trial
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of mouthwash on reducing salivary SARS-CoV-2 viral load and clinical symptoms: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- Efficacy of regular gargling with a cetylpyridinium chloride plus zinc containing mouthwash can reduce upper respiratory symptoms.PloS one · 2025Trial
- Extending regular oral hygiene reduces the incidence of upper respiratory symptoms.Brazilian oral research · 2025Trial
- Novel Fluorinated Chlorhexidine Analogues Overcome Resistance in Gram-Negative Bacteria.ACS omega · 2026Article
- A Chlorhexidine Nanocarrier Strategy to Combat Oral Candidiasis Microcosm Biofilms.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Effectiveness of mouthwashes to reduce the SARS-COV-2 load in saliva of adults with diagnosis of COVID-19: Systematic review and meta-analysis.Journal of clinical and experimental dentistry · 2025Review
- Clinical Activity of Behcet's Disease Associated with SARS-CoV-2 and Herpes Simplex Virus: Insights from Three Case Reports.International medical case reports journal · 2025Article
- Optimizing Ultrasound Probe Disinfection for Healthcare-Associated Infection Control: A Comparative Analysis of Disinfectant Efficacy.Microorganisms · 2024Review
- A New Approach to Evaluate the Bactericidal Activity of Different Antiseptic Ophthalmic Preparations Used as Surgical Prophylaxis.Antibiotics (Basel, Switzerland) · 2024Article
- In Vitro Synergistic Antibacterial Effects of Extract and Honey Derived from Nigella Sativa on Streptococcus Mutans : Antibacterial Effects of Nigella Sativa Extract and Honey.Galen medical journal · 2024Article
- Augmented antiviral activity of chlorhexidine gluconate on herpes simplex virus type 1, H1N1 influenza A virus, and adenovirus in combination with salicylic acid.Archives of virology · 2023Article
- Mouthwash Effects on the Oral Microbiome: Are They Good, Bad, or Balanced?International dental journal · 2023Review
- Antimicrobial Mouthwashes: An Overview of Mechanisms-What Do We Still Need to Know?International dental journal · 2023Review
- Revisiting Oral Antiseptics, Microorganism Targets and Effectiveness.Journal of personalized medicine · 2023Review
- Aerosol in the oral health-care setting: a misty topic.Clinical oral investigations · 2023Review
- Preprocedural mouthwashes for infection control in dentistry-an update.Clinical oral investigations · 2023Review
- Efficacy of Pre-Procedural Mouthwashes against SARS-CoV-2: A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2022Review
- Title Cross-Sectional Study to Evaluate Knowledge and Attitudes on Oral Hygiene of Romanian Students.Medicina (Kaunas, Lithuania) · 2022Article
- The Relationships Among Periodontitis, Pneumonia and COVID-19.Frontiers in oral health · 2021Review
- The efficacy of mouthwashes in reducing SARS-CoV-2 viral loads in human saliva: A systematic review.New microbes and new infectionsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to systematically review the literature about the virucidal efficacy of CHX in comparison to other substances used in the oral cavity. Electronic searches were performed in four databases (PubMed, Scopus, Embase, and Web of Science). Only studies that presented the following characteristics were included: (1) verified virucidal efficacy of CHX against Herpes Simplex Type-1 (HSV-1), any Influenza, or any human coronavirus (HcoV); and (2) compared the virucidal efficacy of CHX with essential oils (Listerine
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.