Evidence map›Paper›PMID 34637084›Full record

ArticleInternal and emergency medicine2022

Response to BNT162b2 mRNA COVID-19 vaccine among healthcare workers in Italy: a 3-month follow-up.

Domenico Ponticelli, Fabiana Madotto, Sara Conti, Ippazio C Antonazzo, Andrea Vitale, Giovanni Della Ragione, Maria L Romano, Mario Borrelli, Beniamino Schiavone, Riccardo Polosa and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Internal and emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Domenico PonticelliPineta Grande Hospital, Castel Volturno, Caserta, Italy.
Fabiana Madotto *Value-Based Healthcare Unit, IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.
Sara Conti *Center for Public Health Research, University of Milan-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Ippazio C Antonazzo *Center for Public Health Research, University of Milan-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Andrea VitalePineta Grande Hospital, Castel Volturno, Caserta, Italy.
Giovanni Della RagionePineta Grande Hospital, Castel Volturno, Caserta, Italy.
Maria L RomanoPineta Grande Hospital, Castel Volturno, Caserta, Italy.
Mario BorrelliPineta Grande Hospital, Castel Volturno, Caserta, Italy.
Beniamino SchiavonePineta Grande Hospital, Castel Volturno, Caserta, Italy.
Riccardo PolosaCenter of Excellence for the Acceleration of HArm Reduction (CoEHAR), University of Catania, Catania, Italy.
Pietro FerraraPineta Grande Hospital, Castel Volturno, Caserta, Italy. p.ferrara5@campus.unimib.it.ORCID 0000-0002-0349-3221
Lorenzo G MantovaniValue-Based Healthcare Unit, IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.
Villa Pineta Hospital · ITMultiMedica · ITUniversity of Milano-Bicocca · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the response to BNT162b2 mRNA COVID-19 vaccine among healthcare workers (HCWs) in an Italian teaching hospital. 444 participants were surveyed with either multiple RT-PCR assays for detection of SARS-CoV-2 nucleic acid in nasopharyngeal swabs or serology testing for the research of virus-specific immunoglobulins. Adverse events following immunization (AEFI) were reported. Two weeks after the first dose anti-SARS-CoV-2 antibodies exceeded reactivity cut-off in 82.5% the participants. Four HCWs tested positive at nasopharyngeal swab after 3 months. More than three-quarters reported AEFIs. Our findings offer an insight regarding the vaccine response after 3 months from its administration, with a special focus on effectiveness data, as well as the type and number of AEFIs complained by HCW recipients. The presented study may serve as reference for future research which will be necessary to explore the long-term safety of this vaccine, especially in population at high risk for infection, such as HCWs.

Indexed as

BNT162 VaccineCOVID-19COVID-19 VaccinesFollow-Up StudiesHealth PersonnelHumansRNA, MessengerSARS-CoV-2BNT162 VaccineCOVID-19 VaccinesRNA, MessengerBNT162b2 vaccineCOVID-19Healthcare workersSARS-CoV-2

Identifiers

PMID34637084
PMCPMC8505466
OpenAlexW3206492771

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.