Evidence map›Paper›PMID 34637060›Full record

ArticleInternational ophthalmology2022

Altered peripapillary vessel density and nerve fiber layer thickness in thyroid-associated ophthalmopathy using optical coherence tomography angiography.

Huan Jian, Yujiao Wang, Luyu Ou, Weimin He

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Huan Jian *Ophthalmic Laboratory, Department of Ophthalmology, West China Hospital, Sichuan University, No. 37 Guoxue Street, Chengdu, 610041, Sichuan, China.
Yujiao Wang *Ophthalmic Laboratory, Department of Ophthalmology, West China Hospital, Sichuan University, No. 37 Guoxue Street, Chengdu, 610041, Sichuan, China.
Luyu OuOphthalmic Laboratory, Department of Ophthalmology, West China Hospital, Sichuan University, No. 37 Guoxue Street, Chengdu, 610041, Sichuan, China.
Weimin HeOphthalmic Laboratory, Department of Ophthalmology, West China Hospital, Sichuan University, No. 37 Guoxue Street, Chengdu, 610041, Sichuan, China. hewm888@hotmail.com.
Sichuan University · CN

Funding

west china hospital, sichuan university 2018HXFH024
6 · The paper itself

Abstract

objectiveTo measure the peripapillary vessel density (VD) and retinal nerve fiber layer thickness (RNFLT) in thyroid-associated ophthalmopathy (TAO) and dysthyroid optic neuropathy (DON) patients using optical coherence tomography angiography (OCTA), and determine their prognostic relevance.

methodsForty-three TAO patients with or without DON (82 eyes in total) and 26 healthy subjects (52 eyes) were enrolled. All participants underwent ophthalmology and endocrinology tests. The peripapillary VD in retinal peripapillary capillary layer and RNFLT were analyzed using OCTA images. Multiple linear regression analysis was used to assess the relationship between peripapillary VD /RNFLT and the relevant factors.

resultsThe total peripapillary VD and RNFLT were significantly lower in the DON patients compared to the other groups (P < 0.001, 95% confidence intervals), and each quadrant of VD and RNFLT showed similar results except temporal RNFLT. No significant difference was seen between the RNFLT and VD of active non-DON (ANDON), inactive non-DON (NDON) patients and normal control (NC) group. Multivariable linear regression model showed that high IOP is an independent risk factor for lower peripapillary VD and RNFLT (β = -0.465, P < 0.001 and β = -0.343, P = 0.002 respectively).

conclusionOCTA parameters are suitable indicators for diagnosing DON. TAO patients with high IOP should be considered at high risk of retinal vessel and nerve fiber layer deterioration. In addition, patients with TAO should be advised to quit smoking since it could affect peripapillary VD and RNFLT.

Indexed as

Graves OphthalmopathyOptic DiskAngiographyFluorescein AngiographyHumansNerve FibersRetinal VesselsTomography, Optical CoherenceDysthyroid optic neuropathyOCTAPeripapillary vessel densityRetinal nerve fiber layer thicknessThyroid-associated ophthalmopathy

Identifiers

PMID34637060
PMCPMC8917016
OpenAlexW3206995964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.