ArticleLasers in medical science2022
Detection of inaccessible head and neck lesions using human saliva and fluorescence spectroscopy.
Article in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Study of the Spectral-Luminescent Properties of Saliva in Patients With Lung Cancer.Journal of biophotonics · 2026Article
- Detection of Stages of Oral Cavity Lesions Using a Fluorescence Portable Device and Their Classification by Artificial Intelligence Tools.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Integration of the fluorescence based portable device with the AI tools for the real-time monitoring of oral mucosal lesions.Scientific reports · 2025Article
- Engineering with Biomedical Sciences Changing the Horizon of Healthcare-A Review.Bioengineered · 2024Review
- Detection of oral mucosal lesions by the fluorescence spectroscopy and classification of cancerous stages by support vector machine.Lasers in medical science · 2024Article
- Human Saliva as a Substitute Diagnostic Medium for the Detection of Oral Lesions Using the Stokes Shift Spectroscopy: Discrimination among the Groups by Multivariate Analysis Methods.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Label-Free Optical Spectroscopy for Early Detection of Oral Cancer.Diagnostics (Basel, Switzerland) · 2022Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head and neck cancer detection using fluorescence spectroscopy from human saliva is reported here. This study has been conducted on squamous cell carcinoma (SCC), and dysplastic (precancer) and control (normal) groups using an in-house developed compact set-up. Fluorescence set-up consists of a 375-nm laser diode and optical components. Spectral bands of flavin adenine dinucleotide (FAD), porphyrins, and Raman are observed in the spectral range of 400 to 800 nm. Presence of FAD and porphyrin bands in human saliva is confirmed by the liquid phantoms of FAD and porphyrin. Significant differences in fluorescence intensities among all the three groups are observed. Three spectral ranges from 455 to 600, 605 to 770, and 400 to 800 nm are selected for each group and area values under each spectral range are computed. To differentiate among the groups, receiver operating characteristic (ROC) analysis is employed on the area values. ROC differentiates among the groups with accuracies of 98%, 92.85%, and 81.13% respectively in the spectral ranges of 400 to 800 nm. However, in other two spectral ranges (455 to 600 and 605 to 770 nm), low accuracy values are found. Obtained accuracy values indicate that selection of human saliva for head and neck cancer detection may be a good alternative.
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