Evidence map›Paper›PMID 34637055›Full record

Trial reportLasers in medical science2022

Erbium, chromium-doped: yttrium, scandium, gallium, garnet and diode lasers in the treatment of peri-implantitis: clinical and biochemical outcomes in a randomized-controlled clinical trial.

Nazli Zeynep Alpaslan Yayli, Ahmet Cemil Talmac, Serap Keskin Tunc, Damla Akbal, Dicle Altindal, Abdullah Seckin Ertugrul

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04730687 nacompletednot on this map

Er,Cr:YSGG and Diode Lasers in the Treatment of Peri-implantitis: A Randomized Clinical Trial

TypeinterventionalSponsorYuzuncu Yil UniversityRan2019 to 2020Enrolled50ConditionsPeri-ImplantitisArmsTraditional non surgical mechanical therapy, Diode laser assisted non-surgical mechancal therapy, Er, Cr: YSGG laser-assisted non-surgical mechanical therapy
NCT06031467 nacompletednot on this map

Evaluation of the Effect of Erbium, Chromium:Yttrium-scandium-gallium-garnet (Er,Cr:YSGG) Laser Application on Peri-Implant Crevicular Fluid RANKL and OPG Levels in the Treatment of Peri-implantitis: A Randomized Clinical Trial

TypeinterventionalSponsorYuzuncu Yil UniversityRan2020 to 2022Enrolled49ConditionsPeri-ImplantitisArmsEr, Cr: YSGG laser-assisted non-surgical mechanical therapy, Non-surgical mechanical therapy
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  13. Peri-Implantitis.Dentistry journal · 2024
    Review
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  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nazli Zeynep Alpaslan YayliFaculty of Dentistry, Department of Periodontology, Van Yuzuncu Yil University, Van, 65080, Turkey. nzeynep_5@hotmail.com.ORCID http://orcid.org/0000-0002-6311-385X
Ahmet Cemil TalmacFaculty of Dentistry, Department of Periodontology, Van Yuzuncu Yil University, Van, 65080, Turkey.ORCID http://orcid.org/0000-0002-7401-0936
Serap Keskin TuncFaculty of Dentistry, Department of Oral and Maxillofacial Surgery, Van Yuzuncu Yil University, Van, Turkey.ORCID http://orcid.org/0000-0001-5439-6598
Damla AkbalFaculty of Dentistry, Department of Periodontology, Van Yuzuncu Yil University, Van, 65080, Turkey.ORCID http://orcid.org/0000-0001-7205-3249
Dicle AltindalFaculty of Dentistry, Department of Periodontology, Van Yuzuncu Yil University, Van, 65080, Turkey.ORCID http://orcid.org/0000-0001-6127-373X
Abdullah Seckin ErtugrulFaculty of Dentistry, Department of Periodontology, Izmir Katip Celebi University, Izmir, Turkey.ORCID http://orcid.org/0000-0002-9973-3161
Van Yüzüncü Yıl Üniversitesi · TRIzmir Kâtip Çelebi University · TR

Funding

Yüzüncü Yil Üniversitesi TSA-2019-8343
6 · The paper itself

Abstract

This study aims to evaluate the effects of 940 nm diode laser and 2780 nm erbium, chromium-doped: yttrium, scandium, gallium, garnet (Er,Cr:YSGG) laser used in addition to mechanical therapy in the non-surgical treatment of peri-implantitis on clinical parameters and matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in the peri-implant crevicular fluid. A total of 50 patients with peri-implantitis were randomized into three groups to receive peri-implant treatment. The control group (n = 17) only received conventional non-surgical mechanical therapy. The trial groups [(diode group (n = 16) and Er,Cr:YSGG group (n = 17)] received dental laser in addition to mechanical therapy. Gingival index (GI), plaque index (PI), bleeding on probing, probing depth (PD), MMP-9, and TIMP-1 levels were assessed at baseline (T0) and at 6 months after treatment (T1). The GI, PI, and PD significantly decreased in all groups at T1, compared to T0 (p < 0.05). The decrease in the PD was similar between the control and diode groups with Er,Cr:YSGG providing more reduction (1.16 ± 0.64 mm) than either method (p = 0.032). A significant intra-group decrease in MMP-9 level was only observed in the Er,Cr:YSGG group (p = 0.009). The decrease in TIMP-1 level from T0 to T1 was similar between the control and the diode groups (p > 0.05) and it was significantly lower than the decrease in the Er,Cr:YSGG group (p < 0.05). Addition of diode laser to non-surgical mechanical therapy does not provide any additional benefit for treatment outcomes. The Er,Cr:YSGG laser seems to be more efficient both at clinical and molecular levels. ClinicalTrials, ID: NCT04730687. Registered 13 April 2021. Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04730687.

Indexed as

GalliumLasers, Solid-StatePeri-ImplantitisChromiumErbiumHumansLasers, SemiconductorScandiumTissue Inhibitor of Metalloproteinase-1YttriumChromiumErbiumGalliumScandiumTissue Inhibitor of Metalloproteinase-1YttriumDiodeEr,Cr:YSGGLaser therapyMMP-9Peri-implantitisTIMP-1

Identifiers

PMID34637055
OpenAlexW3206193322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.