Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2022
Macular vessel density reduction in patients recovered from COVID-19: a longitudinal optical coherence tomography angiography study.
Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Comparison of optic nerve head and macular perfusion changes before and after the development of COVID-19.BMC ophthalmology · 2026Article
- Viral mechanisms, tropism, and clinical relevance regarding the ophthalmic manifestations of SARS-CoV-2 infection.International journal of ophthalmology · 2026Review
- Relationship between anthropometric indices and macular optical coherence tomography angiography in healthy adults from the PERSIAN cohort study.Scientific reports · 2025Observational
- Long-term retinal oximetry and OCT angiography in patients recovered from COVID-19.Scientific reports · 2025Article
- Macular thickness and vascular density assessment using optical coherence tomography and optical coherence tomography angiography imaging in iron ore mine personnel.International journal of retina and vitreous · 2025Article
- Atypical presentation of acute macular neuroretinopathy: a case description.Quantitative imaging in medicine and surgery · 2025Article
- COVID-19's effects on microvascular structure in a healthy retina: an OCTA study.International journal of ophthalmology · 2025Article
- The relationship of macular vessel density and foveal avascular zone with pulse wave velocity and central blood pressure in healthy adults: Persian cohort study.International journal of retina and vitreous · 2024Article
- The neurovascular retinal involvement in a large population of patients recovered from COVID-19: an OCT and OCT angiography study.Eye (London, England) · 2024Observational
- Impaired retinal oxygen metabolism and perfusion are accompanied by plasma protein and lipid alterations in recovered COVID-19 patients.Scientific reports · 2024Article
- New findings on retinal microvascular changes in patients with primary COVID-19 infection: a longitudinal study.Frontiers in immunology · 2024Article
- Outer Retinopathies Associated with COVID-19 Infection: Case Reports and Review of Literature.Case reports in ophthalmological medicine · 2024Article
- Retinal Microvasculature Image Analysis Using Optical Coherence Tomography Angiography in Patients with Post-COVID-19 Syndrome.Journal of imaging · 2023Article
- [Bilateral retinal hemorrhage after acute respiratory distress syndrome (ARDS) with COVID-19 pneumonia].Die Ophthalmologie · 2023Article
- Assessment of early and long-COVID related retinal neurodegeneration with optical coherence tomography.International ophthalmology · 2023Article
- The impact of acute COVID-19 on the retinal microvasculature assessed with multimodal imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Analysis of Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) Parameters in Young Adults after SARS-CoV-2 Infection (COVID-19) Compared with Healthy Young Controls.Diagnostics (Basel, Switzerland) · 2023Article
- The Comparison of Retinal Microvascular Findings in Acute COVID-19 and 1-Year after Hospital Discharge Assessed with Multimodal Imaging-A Prospective Longitudinal Cohort Study.International journal of molecular sciences · 2023Article
- Evaluation of Retinal Microvascular Impairment after COVID-19 and its Clinical Correlates Using Optical Coherence Tomography Angiography.Turkish journal of ophthalmology · 2022Article
- Optical Coherence Tomography Angiography Analysis of Vessel Density Indices in Early Post-COVID-19 Patients.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
aimsTo quantify the longitudinal changes of the macular microvasculature and the foveal avascular zone (FAZ) parameters in patients recovered from coronavirus disease-2019 (COVID-19) using optical coherence tomography angiography (OCTA) analysis.
methodsThis observational, longitudinal study was performed on patients recovered from COVID-19. The OCTA images were recorded at baseline and after 1 and 3 months at the follow-up examination. Vessel density (VD) of the retinal superficial (SCP) and deep capillary plexus (DCP), as well as the area of the FAZ of patients who had recovered from COVID-19, were measured.
resultsIn total, 36 eyes of 18 patients (62.2% female) with a mean age of 34.5 ± 7.5 years old were included. Regarding SCP, while the VDs of the whole image, fovea, and parafovea were comparable at different time points, the mean VDs in inferior hemifield, as well as superior and inferior regions of perifovea, underwent significant reductions at month 3, compared to the baseline. In DCP, the mean of VD in the whole image was 54.3 ± 2.7 at the first visit which significantly decreased to 52.1 ± 3.8(P = 0.003) and 51.4 ± 2.7(P = 0.001) after 1 and 3 months, respectively. The VDs in all regions of parafovea and perifovea revealed a significant reduction after 1 and 3 months, compared to the first visit. The mean FAZ area was 0.27 ± 0.08 mm
conclusionBased on the results, the patients who had recovered from COVID-19 had a progressive decrease of VD at the follow-up visit 3 months after COVID-19 infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.