Evidence map›Paper›PMID 34636937›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

EC

Bart de Laat, Jocelyn Hoye, Heather Liu, Evan D Morris

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Receptor subtype distribution from PET occupancy studies: Novel analysis of maximum occupancy images using a selective drug and a non-selective tracer.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bart de Laat *Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Jocelyn Hoye *Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Heather Liu *Department of Biomedical Engineering, Yale University, CT, New Haven, USA.
Evan D MorrisDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA. evan.morris@yale.edu.
Yale University · US

Funding

PET imaging of Naltrexone Occupancy of Kappa Receptors in Heavy DrinkersR01AA021818 · NIAAA · YALE UNIVERSITY · PI KRISHNAN-SARIN, SUCHITRA, MORRIS, EVAN D · 2013 to 2019
$3.4M
6 · The paper itself

Abstract

purposeWe recently introduced voxel-level images of drug occupancy from PET via our "Lassen plot filter." Occupancy images revealed clear dependence of

methodsFive healthy subjects were scanned with the nonselective GABAa tracer,

resultsAs expected, the EC

conclusionOur results argue for (a) confidence in the ability of the EC

Indexed as

FlumazenilPositron-Emission TomographyBrainHealthy VolunteersHumansPharmaceutical PreparationsFlumazenilPharmaceutical PreparationsDose selectionE max modelLassen plot filterModel selectionSimulations

Identifiers

PMID34636937
OpenAlexW3206969723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.