ArticleInvestigative ophthalmology & visual science2021
Retinal OFF-Pathway Overstimulation Leads to Greater Accommodation-Induced Choroidal Thinning.
Article in Investigative ophthalmology & visual science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Selective i-wave attenuation in unilateral high myopia.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Differential regulation of myopia progression by ON and OFF stimulation in guinea pigs.Eye and vision (London, England) · 2026Article
- Short-Term Effects of Optically Induced and Digitally Simulated Myopic Blur on Retinal Perfusion: Insights From Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2026Article
- Human accommodative visuomotor function is driven by contrast through ON and OFF pathways and is enhanced in myopia.Cell reports · 2026Article
- RLRL Therapeutic Feasibility and Potential Mechanism on Myopia.International journal of molecular sciences · 2025Review
- Increased sensitivity to myopia and altered retinal ON/OFF balance in a mouse model lackingbioRxiv : the preprint server for biology · 2025Article
- Relative Role of ON/OFF Pathways in Resolving and Adapting to Blur in Myopes and Emmetropes.Investigative ophthalmology & visual science · 2025Article
- Age-Related Regional Changes in Choroidal Vascularity in Healthy Emmetropic Eyes.Translational vision science & technology · 2025Article
- Retinal Responses to Short- and Longer-Term Predominant ON or OFF Stimulation in Emmetropes and Myopes.Investigative ophthalmology & visual science · 2025Article
- Corrected Axial Length and Choroidal Thickness: A Correlation Analysis for Scientific Purposes.Journal of personalized medicine · 2025Article
- Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick.Investigative ophthalmology & visual science · 2025Article
- Peripheral Contrast Reduction Optically Induced by Scattering Lenses Thickens Peripheral Choroid.Translational vision science & technology · 2024Article
- Foveal neural adaptation to optically induced contrast reduction.Journal of vision · 2024Article
- Increase in choroidal thickness after blue light stimulation of the blind spot in young adults.Bioelectronic medicine · 2024Article
- Impact of Forms of Visual Attenuation on Short-Term Eye Changes Under Controlled Reading Visibility.Eye and brain · 2024Article
- Association between choriocapillaris perfusion and axial elongation in children using defocus incorporated multiple segments (DIMS) spectacle lenses.Eye (London, England) · 2023Article
- The Role of Retinal Dysfunction in Myopia Development.Cellular and molecular neurobiology · 2023Review
- ON and OFF receptive field processing in the presence of optical scattering.Biomedical optics express · 2023Article
- IMI-The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia.Investigative ophthalmology & visual science · 2023Review
- Studies on the interactions of retinal dopamine with choroidal thickness in the chicken.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To examine the interactions between accommodation and overstimulation of the retinal ON- and OFF-pathways, and their association with changes in choroidal thickness (ChT) and vascularity. Methods: Optical coherence tomography imaging of the choroid of twenty young adults (ages 25 ± 5 years) was performed before and after a series of 30-minute-long viewing tasks, including reading a bright text on dark background (ON-pathway overstimulation) and dark text on bright background (OFF-pathway overstimulation), and a control task of viewing a movie with unbiased ON-/OFF-pathway activation. The viewing tasks were performed with relaxed, and 5 diopter (D) accommodation (induced by soft contact lenses) demands. Both reading texts were matched for the mean luminance (35 cd/m2), luminance contrast (87%), and letter size (approximately 11.8 arc minutes). The change in ChT from baseline associated with contrast polarity and accommodation was examined using linear mixed model analysis. Results: The subfoveal ChT decreased significantly by -7 ± 1 µm with 5 D accommodation compared with relaxed accommodation (-3 ± 1 µm; P < 0.001), and by -9 ± 1 µm with OFF-pathway compared with ON-pathway overstimulation (-4 ± 1 µm; P = 0.002) and the control condition (-2 ± 1 µm; P < 0.001). Overstimulation of the OFF-pathway, but not the ON-pathway, resulted in a significantly greater choroidal thinning compared with the control condition, both at relaxed (-7 ± 1 µm; P = 0.003) and 5 D (-11 ± 1 µm; P = 0.005) accommodation levels. Similar changes were also observed for macular total, stromal, and luminal ChT. Conclusions: Retinal OFF-pathway stimulation enhanced the choroidal thinning associated with accommodation, thereby providing a potential mechanism that involves accommodation and the retinal OFF-signaling pathway, linking near work and myopia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.