ArticleCartilage2021
Three-Dimensional-Printed External Scaffolds Mitigate Loss of Volume and Topography in Engineered Elastic Cartilage Constructs.
Article in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Bioengineered nasal septum implant with 3D-printed silicone and chondrocyte-seeded fibrin hydrogel.Regenerative biomaterials · 2026Article
- Innovative tissue engineering strategies for auricular regeneration in microtia: Current advances and future perspectives.Regenerative therapy · 2025Review
- Polydeoxynucleotide-Loaded Visible Light Photo-Crosslinked Gelatin Methacrylate Hydrogel: Approach to Accelerating Cartilage Regeneration.Gels (Basel, Switzerland) · 2025Article
- 3D printing tissue-engineered scaffolds for auricular reconstruction.Materials today. Bio · 2024Review
- Evaluation of Bioprinted Autologous Cartilage Grafts in an Immunocompetent Rabbit Model.Advanced therapeutics · 2024Article
- Bioengineering Full-scale auricles using 3D-printed external scaffolds and decellularized cartilage xenograft.Acta biomaterialia · 2024Article
- Recent advances in 3D bioprinted cartilage-mimicking constructs for applications in tissue engineering.Materials today. Bio · 2023Review
- Combining bioengineered human skin with bioprinted cartilage for ear reconstruction.Science advances · 2023Article
- Alginate Conjugation Increases Toughness in Auricular Chondrocyte Seeded Collagen Hydrogels.Bioengineering (Basel, Switzerland) · 2023Article
- Upregulated desmin/integrin β1/MAPK axis promotes elastic cartilage regeneration with increased ECM mechanical strength.International journal of biological sciences · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveA major obstacle in the clinical translation of engineered auricular scaffolds is the significant contraction and loss of topography that occur during maturation of the soft collagen-chondrocyte matrix into elastic cartilage. We hypothesized that 3-dimensional-printed, biocompatible scaffolds would "protect" maturing hydrogel constructs from contraction and loss of topography.
designExternal disc-shaped and "ridged" scaffolds were designed and 3D-printed using polylactic acid (PLA). Acellular type I collagen constructs were cultured
resultsThe presence of an external scaffold or use of injection molding methodology did not affect the acellular construct volume or base area loss.
conclusionCustom-designed, 3D-printed, biocompatible external scaffolds significantly mitigate BAuC-seeded construct contraction and maintain complex topography. Further refinement and scaling of this approach in conjunction with construct fabrication utilizing injection molding may aid in the development of full-scale auricular scaffolds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.