Evidence map›Paper›PMID 34636458›Full record

ArticleNMR in biomedicine2022

A hybrid numeric-analytic solution for pulsed CEST.

Christopher L Lankford, Elizabeth A Louie, Zhongliang Zu, Mark D Does, Daniel F Gochberg

Open access · greenAbstract read
In one paragraph

Article in NMR in biomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christopher L LankfordVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States.
Elizabeth A LouieVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States.
Zhongliang ZuVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States.ORCID 0000-0001-7361-7480
Mark D DoesVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States.
Daniel F GochbergVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States.ORCID 0000-0003-3708-1310
Vanderbilt University · US

Funding

Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
CERT Imaging of CancerR01CA184693 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOCHBERG, DANIEL F · 2014 to 2018
$1.6M
CERT Imaging of MuscleR01EB017767 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOCHBERG, DANIEL F · 2014 to 2017
$1.4M
NCI NIH HHS R01 CA184693NIBIB NIH HHS R01 EB017767NIBIB NIH HHS T32 EB001628
6 · The paper itself

Abstract

Chemical exchange saturation transfer (CEST) methods measure the effect of magnetization exchange between solutes and water. While CEST methods are often implemented using a train of off-resonant shaped RF pulses, they are typically analyzed as if the irradiation were continuous. This approximation does not account for exchange of rotated magnetization, unique to pulsed irradiation and exploited by chemical exchange rotation transfer methods. In this work, we derive and test an analytic solution for the steady-state water signal under pulsed irradiation by extending a previous work to include the effects of pulse shape. The solution is largely accurate at all offsets, but this accuracy diminishes at higher exchange rates and when applying pulse shapes with large root-mean-squared to mean ratios (such as multi-lobe sinc pulses).

Indexed as

Numerical Analysis, Computer-AssistedImage Interpretation, Computer-AssistedMagnetic Resonance ImagingValidation Studies as Topicanalytic solutionCERTCESTexchangeR1ρR2ρ

Identifiers

PMID34636458
PMCPMC9045009
OpenAlexW3207334463

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.