Evidence map›Paper›PMID 34636423›Full record

ArticleThe Journal of comparative neurology2022

Ultrastructure of ipsilateral and contralateral tectopulvinar projections in the mouse.

Nazratan Naeem, James Bowman Whitley, Arkadiusz S Slusarczyk, Martha Elise Bickford

Open access · greenAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Individual Pulvinar Neurons Integrate Cortical and Subcortical Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Behavioral Modulation and Molecular Definition of Wide-Field Vertical Cells in the Mouse Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nazratan NaeemAnatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky, USA.
James Bowman WhitleyAnatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky, USA.
Arkadiusz S SlusarczykAnatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky, USA.
Martha Elise BickfordAnatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky, USA.ORCID 0000-0002-0259-7395
University of Louisville · US

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
WaNPRC Macaca nemestrina SPF Breeding ColonyU42OD011123 · OD · UNIVERSITY OF WASHINGTON · PI CHARLOTTE HOTCHKISS · 2012 to 2026
$34.4M
Midbrain Circuits for Perceptual Decision-MakingUF1NS122040 · NINDS · UNIVERSITY OF VIRGINIA · PI BASSO, MICHELE A, BICKFORD, MARTHA E · 2021 to 2023
$3.8M
Parallel Tectothalamic PathwaysR01EY024173 · NEI · UNIVERSITY OF LOUISVILLE · PI BICKFORD, MARTHA E, GUIDO, WILLIAM · 2014 to 2019
$2.7M
Parallel Pulvinar PathwaysR01EY031322 · NEI · UNIVERSITY OF LOUISVILLE · PI BICKFORD, MARTHA E, GUIDO, WILLIAM · 2020 to 2023
$1.9M
STUDY OF METHYL-S-COENZYME M REDUCTASEF32GM010342 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WACKETT, LAWRENCE P · 1985 to 1985
–
NEI NIH HHS R01 EY024173NEI NIH HHS R01 EY031322NIGMS NIH HHS P20 GM103436NIH HHS U42 OD011123NINDS NIH HHS U01 NS122040NINDS NIH HHS UF1 NS122040
6 · The paper itself

Abstract

Visual pathways of the brain are organized into parallel channels that code different features of the external environment. In the current study, we investigated the anatomical organization of parallel pathways from the superior colliculus (SC) to the pulvinar nucleus in the mouse. Virus injections placed in the ipsilateral and contralateral SC to induce the expression of different fluorescent proteins define two pulvinar zones. The lateral pulvinar (Pl) receives ipsilateral SC input and the caudal medial pulvinar (Pcm) receives bilateral SC input. To examine the ultrastructure of these projections using transmission electron microscopy, we injected the SC with viruses to induce peroxidase expression within synaptic vesicles or mitochondria. We quantitatively compared the sizes of ipsilateral and contralateral tectopulvinar terminals and their postsynaptic dendrites, as well as the sizes of the overall population of synaptic terminals and their postsynaptic dendrites in the Pl and Pcm. Our ultrastructural analysis revealed that ipsilateral tectopulvinar terminals are significantly larger than contralateral tectopulvinar terminals. In particular, the ipsilateral tectopulvinar projection includes a subset of large terminals (≥ 1 μm

Indexed as

PulvinarAnimalsMicePresynaptic TerminalsSuperior ColliculiVisual Pathwayselectron microscopypulvinarsuperior colliculussynapsevesiclewidefield vertical

Identifiers

PMID34636423
PMCPMC8957504
OpenAlexW3206149837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.