ArticleAnnals of clinical and translational neurology2021
Lack of progression of beta dynamics after long-term subthalamic neurostimulation.
Article in Annals of clinical and translational neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Beta-Band and Aperiodic Activity Across New and Chronic Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Temporal Dynamics of Microlesion Effects in Subthalamic Local Field Potentials.Neurologia medico-chirurgica · 2026Article
- Long-term consistency of aperiodic and periodic physiomarkers in subthalamic local field potentials in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Long-Term Stability of Spatial Distribution and Peak Dynamics of Subthalamic Beta Power in Parkinson's Disease Patients.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Comparison of beta peak detection algorithms for data-driven deep brain stimulation programming strategies in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Current and future applications of local field potential-guided programming for Parkinson's disease with the Percept™ rechargeable neurostimulator.Neurodegenerative disease management · 2024Review
- Cognitive aspects of motor control deteriorate while off treatment following subthalamic nucleus deep brain stimulation surgery in Parkinson's disease.Frontiers in neurology · 2024Article
- Bradykinesia and Its Progression Are Related to Interhemispheric Beta Coherence.Annals of neurology · 2023Article
- Closed-Loop Adaptive Deep Brain Stimulation in Parkinson's Disease: Procedures to Achieve It and Future Perspectives.Journal of Parkinson's disease · 2023Review
- Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings.NPJ Parkinson's disease · 2022Article
- Novel approaches for quantifying beta synchrony in Parkinson's disease.Experimental brain research · 2022Review
- Quantitative Digitography Measures Motor Symptoms and Disease Progression in Parkinson's Disease.Journal of Parkinson's disease · 2022Article
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the progression of neural and motor features of Parkinson's disease in a longitudinal study, after washout of medication and bilateral subthalamic nucleus deep brain stimulation (STN DBS).
methodsParticipants with clinically established Parkinson's disease underwent bilateral implantation of DBS leads (18 participants, 13 male) within the STN using standard functional frameless stereotactic technique and multi-pass microelectrode recording. Both DBS leads were connected to an implanted investigative sensing neurostimulator (Activa™ PC + S, Medtronic, PLC). Resting state STN local field potentials (LFPs) were recorded and motor disability, (the Movement Disorder Society-Unified Parkinson's Disease Rating Scale - motor subscale, MDS-UPDRS III) was assessed off therapy at initial programming, and after 6 months, 1 year, and yearly out to 5 years of treatment. The primary endpoint was measured at 3 years. At each visit, medication had been held for over 12/24 h and DBS was turned off for at least 60 min, by which time LFP spectra reached a steady state.
resultsAfter 3 years of chronic DBS, there were no increases in STN beta band dynamics (p = 0.98) but there were increases in alpha band dynamics (p = 0.0027, 25 STNs). Similar results were observed in a smaller cohort out to 5 years. There was no increase in the MDS-UPDRS III score.
interpretationThese findings provide evidence that the beta oscillopathy does not substantially progress following combined STN DBS plus medication in moderate to advanced Parkinson's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.