Evidence map›Paper›PMID 34636156›Full record

Trial reportCancer medicine2021

Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High-intensity Aerobic and resistance exercise for Metastatic castrate-resistant Prostate cancer.

Stacey A Kenfield, Erin L Van Blarigan, Neil Panchal, Alexander Bang, Li Zhang, Rebecca E Graff, Yea-Hung Chen, Charles J Ryan, Anthony Luke, Robert U Newton and 13 more

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06451120 (Study of Platelet Rich Plasma), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06451120 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Study of Platelet Rich Plasma (PRP) Injections With Symptomatic Knee Osteoarthritis for Biomarker Exploration in Young and Old Human Subjects

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2027Enrolled60ConditionsOsteoarthritis, Articular Cartilage, Musculoskeletal DisordersArmsPlatelet-Rich Plasma (PRP) Injections, Centrifuge, Control saline injection
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Using digital technology to support wellbeing and independence among people living with incurable cancers: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 2 countries.

Stacey A KenfieldUniversity of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-1585-7352
Erin L Van BlariganUniversity of California, San Francisco, San Francisco, California, USA.
Neil PanchalUniversity of California, San Francisco, San Francisco, California, USA.
Alexander BangUniversity of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-1700-2411
Li ZhangUniversity of California, San Francisco, San Francisco, California, USA.
Rebecca E GraffUniversity of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-0316-8303
Yea-Hung ChenUniversity of California, San Francisco, San Francisco, California, USA.
Charles J RyanUniversity of California, San Francisco, San Francisco, California, USA.
Anthony LukeUniversity of California, San Francisco, San Francisco, California, USA.
Robert U NewtonEdith Cowan University, Perth, Australia.
Imelda TenggaraUniversity of California, San Francisco, San Francisco, California, USA.
Brooke SchultzUniversity of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-4407-395X
Elizabeth WangColumbia University, New York, New York, USA.
Emil LavakiUniversity of California, San Francisco, San Francisco, California, USA.
Kyle ZunigaUniversity of California, San Francisco, San Francisco, California, USA.
Nicole PintoUniversity of California, San Francisco, San Francisco, California, USA.
Hala BornoUniversity of California, San Francisco, San Francisco, California, USA.
Rahul AggarwalUniversity of California, San Francisco, San Francisco, California, USA.
Terence FriedlanderUniversity of California, San Francisco, San Francisco, California, USA.
Vadim S KoshkinUniversity of California, San Francisco, San Francisco, California, USA.
Andrea HarzstarkKaiser Permanente Oakland Medical Center, Oakland, California, USA.
Eric SmallUniversity of California, San Francisco, San Francisco, California, USA.
June M ChanUniversity of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USColumbia University · USEdith Cowan University · AUKaiser Permanente Oakland Medical Center · USUniversity of Minnesota · US

Funding

Diet After Colorectal Cancer : Observational Studies to Behavioral InterventionsK07CA197077 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAN BLARIGAN, ERIN LYNN · 2016 to 2020
$885k
A Randomized Clinical Trial of Exercise for Men with Metastatic Prostate CancerR21CA184605 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KENFIELD, STACEY · 2015 to 2016
$379k
NCI NIH HHS K07 CA197077NCI NIH HHS K07CA197077NCI NIH HHS R21 CA184605
6 · The paper itself

Abstract

backgroundExercise may improve clinical and quality of life outcomes for men with prostate cancer. No randomized controlled trials (RCTs) have examined the feasibility, safety, and acceptability of remote exercise training in men with metastatic castrate-resistant prostate cancer (mCRPC).

methodsWe conducted a pilot RCT (1:1:1 aerobic or resistance exercise 3x/week or usual care) to determine the feasibility, safety, and acceptability of remotely monitored exercise over 12 weeks in 25 men with mCRPC. A prescribed exercise program was based on baseline testing including high- and moderate-intensity aerobic exercise or resistance exercise completed at a local exercise facility. Feasibility was based on attendance, adherence, and tolerance; safety on adverse events; and acceptability on participant interviews.

resultsBetween March 2016 and March 2020, 25 patients were randomized (8 aerobic, 7 resistance, and 10 control). Twenty-three men (82%) completed the 12-week study. Men who completed the remote intervention attempted 90% and 96% of prescribed aerobic and resistance training sessions, respectively, and 86% and 88% of attempted sessions were completed as or more than prescribed. We observed changes in performance tests that corresponded with the exercise prescription. No safety concerns were identified. Ninety percent of participants interviewed were satisfied with the program and would recommend it to others.

conclusionsRemotely monitored exercise training is feasible, safe, and acceptable in men with mCRPC; there was no difference in these outcomes by mode of exercise. Through this research, we provide direction and rationale for future studies of exercise and clinical outcomes in patients with metastatic prostate cancer.

Indexed as

AgedAged, 80 and overExerciseFeasibility StudiesHumansMaleMiddle AgedNeoplasm MetastasisPilot ProjectsProstatic Neoplasms, Castration-Resistantbehavioral interventionphysical activityremotestrength training

Identifiers

PMID34636156
PMCPMC8607248
OpenAlexW3206653859

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.