ArticleAdvanced materials (Deerfield Beach, Fla.)2021
Predictably Engineering the Viscoelastic Behavior of Dynamic Hydrogels via Correlation with Molecular Parameters.
Article in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Post-fabrication reconfiguration of hydrogels through thermodynamic asymmetry in dynamic chemistry.Nature communications · 2026Article
- Tough and Rapidly Relaxing Hydrogels Via Programmable Crosslink Kinetics.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Dynamic matrix engineering promotes nascent protein deposition to drive cell migration and expedite Re-epithelization in chronic wound.Bioactive materials · 2026Article
- Review
- Advanced cell-adaptable hydrogels for bioprinting.Bioactive materials · 2025Review
- Catalyst-modulated hydrogel dynamics for decoupling viscoelasticity and directing macrophage fate for diabetic wound healing.Bioactive materials · 2025Article
- Kinetic Locking of pH-Sensitive Complexes for Mechanically Responsive Polymer Networks.Journal of the American Chemical Society · 2025Article
- Extracellular Matrix Viscoelasticity: A Dynamic Regulator of Cellular Behavior.Annals of biomedical engineering · 2025Review
- Hydrogel Network Architecture Design Space: Impact on Mechanical and Viscoelastic Properties.Gels (Basel, Switzerland) · 2025Review
- Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation.Nature communications · 2025Article
- Design and Fabrication of Viscoelastic Hydrogels as Extracellular Matrix Mimicry for Cell Engineering.Chem & bio engineering · 2024Review
- Cross-Linker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels.Advanced healthcare materials · 2024Article
- Tunable Viscoelasticity of Alginate Hydrogels via Serial Autoclaving.Advanced healthcare materials · 2024Article
- Tuning porosity of macroporous hydrogels enables rapid rates of stress relaxation and promotes cell expansion and migration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Structure-Reactivity Relationships in a Small Library of Imine-Type Dynamic Covalent Materials: Determination of Rate and Equilibrium Constants Enables Model Prediction and Validation of a Unique Mechanical Softening in Dynamic Hydrogels.Journal of the American Chemical Society · 2024Article
- Advancing Synthetic Hydrogels through Nature-Inspired Materials Chemistry.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Well-Defined Synthetic Copolymers with Pendant Aldehydes Form Biocompatible Strain-Stiffening Hydrogels and Enable Competitive Ligand Displacement.Journal of the American Chemical Society · 2024Article
- Rapidly damping hydrogels engineered through molecular friction.Nature communications · 2024Article
- Crosslinker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels.bioRxiv : the preprint server for biology · 2024Article
- Internal Catalysis in Dynamic Hydrogels with Associative Thioester Cross-Links.ACS macro letters · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
Rational design of dynamic hydrogels with desirable viscoelastic behaviors relies on an in-depth understanding of the principles correlating molecular parameters and macroscopic properties. To quantitatively elucidate such principles, a series of dynamic covalent hydrogels crosslinked via hydrazone bonds is designed. The exchange rate of the hydrazone bond is tuned by varying the concentration of an organic catalyst, while maintaining the crosslinking density unchanged. This strategy of independently tuning exchange dynamics of crosslinks and crosslinking density allows unambiguous analysis of the viscoelastic response of the dynamic hydrogels as a function of their network parameters. It is found that the terminal relaxation time of the dynamic hydrogels is primarily determined by two factors: the exchange rate of crosslinks and the number of effective crosslinks per polymer chain, and is independent of the network architecture. Furthermore, a universal correlation is identified between the terminal relaxation time determined from stress relaxation and the exchange rate determined via reaction kinetics, which can be generalized to any viscoelastic hydrogel network, in principle. This quantitative correlation facilitates the development of dynamic hydrogels with a variable desired viscoelastic response based on molecular design.
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