Evidence map›Paper›PMID 34636033›Full record

ArticleBritish journal of haematology2022

COVID-19 infection in chronic myeloid leukaemia after one year of the pandemic in Italy. A Campus CML report.

Massimo Breccia, Elisabetta Abruzzese, Vincenzo Accurso, Immacolata Attolico, Sara Barulli, Micaela Bergamaschi, Gianni Binotto, Monica Bocchia, Massimiliano Bonifacio, Giovanni Caocci and 39 more

Open access · bronzeAbstract read
In one paragraph

Article in British journal of haematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

49 authors at 20 institutions in 1 country.

Massimo BrecciaDepartment of Translational and Precision Medicine, Sapienza University, Roma, Italy.ORCID 0000-0003-1163-6162
Elisabetta AbruzzeseSant Eugenio Hospital, Hematology, Roma, Italy.ORCID 0000-0001-5228-6491
Vincenzo AccursoUO di Ematologia con Trapianto, AU Policlinico Paolo Giaccone, Palermo, Italy.
Immacolata AttolicoUO Ematologia con Trapianto, Università degli Studi di Bari Aldo Moro, Bari, Italy.ORCID 0000-0002-3527-3151
Sara BarulliDivisione di Ematologia di Muraglia, CTMO Ospedale San Salvatore, Pesaro, Italy.
Micaela BergamaschiEmatologia, Ospedale Santa Corona, Pietra Ligure, Italy.
Gianni BinottoEmatologia ed Immunologia Clinica, Università degli Studi di Padova, Padova, Italy.ORCID 0000-0003-4571-6611
Monica BocchiaU.O.C. Ematologia e Trapianti, A.O. Senese - Policlinico 'Le Scotte', Siena, Italy.
Massimiliano BonifacioDivisione di Ematologia, Istituti Ospitalieri di Verona, Policlinico G.B. Rossi, Verona, Italy.ORCID 0000-0003-0716-1686
Giovanni CaocciCTMO - Ematologia, Ospedale 'Businco', Cagliari, Italy.ORCID 0000-0002-6585-5187
Isabella CapodannoEmatologia, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy.
Fausto CastagnettiIstituto di Ematologia 'Lorenzo e A. Seragnoli', Policlinico S. Orsola-Malpighi, Bologna, Italy.
Francesco CavazziniEmatologia, Arcispedale Sant'Anna, Ferrara, Italy.
Elena CrisàS.C.D.U. Ematologia - DIMECS e Dipartimento Oncologico, Università del Piemonte Orientale Amedeo Avogadro, Novara, Italy.
Monica CrugnolaEmatologia, Università degli Studi di Parma, Parma, Italy.
Maria Stella De CandiaUOC Ematologia con Trapianto, Brindisi Hospital, Brindisi, Italy.
Chiara ElenaEmatologia, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.
Carmen FavaA.S.O. Ordine Mauriziano, P.O. Umberto I, Struttura Complessa a Direzione Universitaria-Ematologia e Terapie Cellulari, Torino, Italy.
Sara GalimbertiEmatologia, Università di Pisa - Azienda Ospedaliera Pisana, Pisa, Italy.
Antonella GozziniUnità di Ricerca e di Malattie del Sangue, Ematologia San Luca Vecchio, Firenze, Italy.
Gabriele GugliottaIstituto di Ematologia 'Lorenzo e A. Seragnoli', Policlinico S. Orsola-Malpighi, Bologna, Italy.
Tamara IntermesoliHematology, Bergamo Hospital, Bergamo, Italy.
Alessandra IurloUOC Ematologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Gaetano La BarbaU.O. Ematologia Clinica, Azienda USL di Pescara, Pescara, Italy.
Roberto LatagliataEmatologia, Ospedale Belcolle, Viterbo, Italy.ORCID 0000-0002-7741-862X
Sabrina Leonetti CrescenziEmatologia, Ospedale S. Giovanni Addolorata, Roma, Italy.
Luciano LevatoEmatologia, Ospedale Catanzaro, Catanzaro, Italy.
Giuseppina LoglisciEmatologia, Ospedale Lecce, Lecce, Italy.
Alessandro LucchesiEmatologia, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.ORCID 0000-0002-0624-5311
Luigiana LucianoEmatologia, Azienda Ospedaliera Universitaria - Università degli Studi di Napoli 'Federico II', Napoli, Italy.
Francesca LunghiEmatologia, Ospedale S. Raffaele, Milano, Italy.
Debora LuziEmatologia, A.O. Santa Maria - Terni S.C Oncoematologia, Terni, Italy.
Alessandra MalatoEmatologia, Ospedali Riuniti 'Villa Sofia-Cervello', Palermo, Italy.
Maria Cristina MiggianoEmatologia, Ospedale Vicenza, Vicenza, Italy.
Michele PizzutiEmatologia, Ospedale Potenza, Potenza, Italy.
Patrizia PregnoDipartimento di Oncologia ed Ematologia S.C. Ematologia 2, A.O. Città della Salute e della Scienza di Torino S. G. Battista, Torino, Italy.
Davide RapezziEmatologia, Ospedale Cuneo, Cuneo, Italy.
Giovanna Rege-CambrinDipartimento di Scienze Cliniche e Biologiche, Ospedale S. Luigi Gonzaga-Medicina Interna 2, Orbassano, Italy.
Gianantonio RostiEmatologia, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.
Sabina RussoDipartimento di Medicina Interna, Azienda Ospedaliera Universitaria - Policlinico G. Martino, Messina, Italy.
Rosaria SancettaEmatologia, Ospedale Mestre, Mestre, Italy.
Anna Rita ScortechiniEmatologia, Azienda Ospedaliero - Universitaria Ospedali Riuniti, Ancona, Italy.
Federica SoràEmatologia, Policlinico Gemelli - Università Cattolica del Sacro Cuore, Roma, Italy.ORCID 0000-0002-9607-5298
Paolo SportolettiEmatologia, Ospedale Perugia, Perugia, Italy.ORCID 0000-0002-5630-9862
Fabio StagnoHematology Section and BMT Unit, AOU Policlinico 'Rodolico-San Marco', Catania, Italy.
Agostino TafuriEmatologia, AOU S. Andrea, Roma, Italy.
Mario TiribelliClinica Ematologica-Centro Trapianti e Terapie cellulari, Azienda Ospedaliero-Universitaria, Udine, Italy.ORCID 0000-0001-9449-2621
Robin FoàDepartment of Translational and Precision Medicine, Sapienza University, Roma, Italy.
Giuseppe SaglioA.S.O. Ordine Mauriziano, Struttura Complessa a Direzione Universitaria-Ematologia e Terapie Cellulari-, P.O. Umberto I, Torino, Italy.ORCID 0000-0002-1046-3514
A. O. Ordine Mauriziano di Torino · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITSapienza University of Rome · ITAccademia di Belle Arti di Catanzaro · ITArcispedale Sant'Anna · ITAzienda Ospedaliera San Giovanni Addolorata · ITAzienda Ospedaliera S.Maria · ITAzienda Ospedaliera Universitaria Policlinico "G. Martino" · ITAzienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · ITAzienda Ospedaliera Universitaria Senese · ITAzienda Ospedaliero Universitaria Ospedali Riuniti · ITAzienda Sanitaria Ospedaliera S.Croce e Carle Cuneo · ITAzienda Sanitaria Unità Locale di Reggio Emilia · ITAzienda USL di Pescara · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITInternational Renal Research Institute of Vicenza · ITIRCCS Ospedale San Raffaele · ITIstituto di Ematologia di Bologna · ITIstituto Nazionale di Fisica Nucleare, Sezione di Lecce · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited information is available on the impact of the COVID-19 pandemic on the management of chronic myeloid leukaemia (CML). The Campus CML network collected retrospective information on 8 665 CML patients followed at 46 centres throughout Italy during the pandemic between February 2020 and January 2021. Within this cohort, we recorded 217 SARS-CoV-2-positive patients (2·5%). Most patients (57%) were diagnosed as having SARS-CoV-2 infection during the second peak of the pandemic (September 2020 to January 2021). The majority (35%) was aged between 50 and 65 years with a male prevalence (73%). Fifty-six percent of patients presented concomitant comorbidities. The median time from CML diagnosis to SARS-CoV-2 infection was six years (three months to 18 years). Twenty-one patients (9·6%) required hospitalization without the need of respiratory assistance, 18 (8·2%) were hospitalized for respiratory assistance, 8 (3·6%) were admitted to an intensive care unit, while 170 (78%) were only quarantined. Twenty-three percent of patients discontinued tyrosine kinase inhibitor (TKI) therapy during the infection. Twelve patients died due to COVID-19 with a mortality rate of 5·5% in the positive cohort and of 0·13% in the whole cohort. We could also document sequelae caused by the SARS-CoV-2 infection and an impact of the pandemic on the overall management of CML patients.

Indexed as

COVID-19Leukemia, Myelogenous, Chronic, BCR-ABL PositivePandemicsSARS-CoV-2AgedDisease-Free SurvivalFemaleHumansItalyMaleMiddle AgedRetrospective StudiesSurvival Ratechronic myeloid leukemiaCovid-19mortalityprognosis

Identifiers

PMID34636033
PMCPMC8652631
OpenAlexW3205785046

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.