Evidence map›Paper›PMID 34636022›Full record

Observational studyClinical rheumatology2022

Impact of smoking habit on adult-onset Still's disease prognosis, findings from a multicentre observational study.

Piero Ruscitti, Ilenia Di Cola, Onorina Berardicurti, Alessandro Conforti, Daniela Iacono, Ilenia Pantano, Gelsomina Rozza, Silvia Rossi, Ludovico De Stefano, Silvia Balduzzi and 14 more

Erratum issuedAbstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 1 country.

Piero RuscittiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, delta 6 building, PO box 67100, L'Aquila, Italy. piero.ruscitti@univaq.it.ORCID http://orcid.org/0000-0003-3487-8551
Ilenia Di ColaDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, delta 6 building, PO box 67100, L'Aquila, Italy.
Onorina BerardicurtiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, delta 6 building, PO box 67100, L'Aquila, Italy.
Alessandro ConfortiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, delta 6 building, PO box 67100, L'Aquila, Italy.
Daniela IaconoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Ilenia PantanoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Gelsomina RozzaDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Silvia RossiRheumatology Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Ludovico De StefanoRheumatology Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Silvia BalduzziRheumatology Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Antonio VitaleResearch Center of Systemic Auto Inflammatory Diseases, Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Rheumatology Unit, Policlinico "Le Scotte", Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Francesco CasoDeparment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Luisa CostaDeparment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Marcella PreteRheumatic and Systemic Autoimmune Diseases Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari Medical School, Bari, Italy.
Luca NavariniRheumatology and Immunology Unit, Department of Medicine, University of Rome Campus Biomedico, Rome, Italy.
Fabiola AtzeniRheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Giuliana GugginoRheumatology Section, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University Hospital "P. Giaccone", Palermo, Italy.
Federico PerosaRheumatic and Systemic Autoimmune Diseases Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari Medical School, Bari, Italy.
Luca CantariniResearch Center of Systemic Auto Inflammatory Diseases, Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Rheumatology Unit, Policlinico "Le Scotte", Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Bruno FredianiResearch Center of Systemic Auto Inflammatory Diseases, Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Rheumatology Unit, Policlinico "Le Scotte", Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Carlomaurizio MontecuccoRheumatology Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Francesco CicciaDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Roberto GiacomelliRheumatology and Immunology Unit, Department of Medicine, University of Rome Campus Biomedico, Rome, Italy.
Paola CiprianiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, delta 6 building, PO box 67100, L'Aquila, Italy.
University of L'Aquila · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Pavia · ITUniversity of Siena · ITUniversità Campus Bio-Medico · ITUniversity of Bari Aldo Moro · ITUniversity of Naples Federico II · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study is to describe the possible prognostic impact of smoking habit on adult-onset Still's disease (AOSD) patients, by the assessment of clinical characteristics, life-threatening complications occurrence, and mortality in smokers than non-smokers. A multicentre retrospective study of prospectively followed-up AOSD patients included in Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort was conducted. Out of 185 AOSD assessed patients, 45 smokers were identified. These showed a higher frequency of pericarditis (35.5% vs 16.4%, p = 0.011), pleuritis (33.3% vs 14.3%, p = 0.008), and abdominal pain (17.7% vs 6.4%, p = 0.035). Furthermore, smokers showed higher values of systemic score (6.4 ± 2.2 vs 5.4 ± 1.8, p = 0.004), an increased rate of macrophage activation syndrome (MAS) (28.9% vs 6.4%, p < 0.0001) and of parenchymal lung disease (17.7% vs 12.6%, p = 0.035). Although not significant, these patients more frequently experienced a poor prognosis (13.3% vs 4.3%, p = 0.074). Smoking habit predicted MAS occurrence in both univariate (HR: 5.98, 95% CI: 2.45-14.57, p < 0.0001) and multivariate regression models (HR: 6.21, 95% CI: 2.46-15.70, p < 0.0001). Smokers had a significant higher risk of parenchymal lung disease in both univariate (HR: 3.97, 95% CI: 1.43-11.02, p = 0.008) and multivariate regression models (HR: 3.90, 95% CI: 1.36-11.23, p = 0.012). Smoking habit also increased the risk of mortality in univariate regression model (HR: 4.25, 95% CI: 1.33-13.55, p = 0.015). Smoking habit resulted to be a negative prognostic factor on AOSD patients. Smokers were characterised by a higher frequency of serositis and higher values of systemic score. Additionally, these patients were more frequently burdened by MAS and parenchymal lung disease associated with a poor prognosis. Key points • Smoking habit resulted to be a negative prognostic factor on AOSD. • Smokers were characterised by an increased frequency of serositis and higher values of systemic score. • Cigarette exposure was associated with MAS and parenchymal lung disease in AOSD.

Indexed as

Macrophage Activation SyndromeStill's Disease, Adult-OnsetAdultHumansPrognosisRetrospective StudiesSmokingAdult-onsetMacrophage activation syndromeMortalitySmokingStill’s disease

Identifiers

PMID34636022
OpenAlexW3205614341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.