ReviewNature reviews. Microbiology2022
Lipid biomarkers: molecular tools for illuminating the history of microbial life.
Review in Nature reviews. Microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 106 citations in OpenAlex.
- Mechanistic insight into radicalNatural product reports · 2026Review
- Tectonic setting shapes microbial biosynthetic potential across global geothermal environments.bioRxiv : the preprint server for biology · 2026Article
- Machine learning-based paleobathymetric reconstructions using archaeal lipid biomarkers.Science advances · 2026Article
- Advancing Clinical and Pathophysiological Insights into Pancreatitis Using Lipidomics and Metabolomics.Metabolites · 2025Review
- A diverse Palaeoproterozoic microbial ecosystem implies early eukaryogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Temperature-Sensitive Lipids Reveal Intraspecific Diversity in Bacteria Isolated from an Ancient Antarctic Microbial Mat.Microbial ecology · 2025Article
- Rapid reshaping of the soil microbiome and metabolome during short-term flooding and draining in rice.Frontiers in microbiology · 2025Article
- Substantial contribution ofISME communications · 2025Article
- Unusual Genomic and Biochemical Features ofInternational journal of molecular sciences · 2024Article
- Structure Diversity and Properties of Some Bola-like Natural Products.Marine drugs · 2024Review
- The eukaryome of modern microbialites reveals distinct colonization across aquatic ecosystems.NPJ biofilms and microbiomes · 2024Article
- Nitrogen and sulfur for phosphorus: Lipidome adaptation of anaerobic sulfate-reducing bacteria in phosphorus-deprived conditions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Review
- Strong linkage between benthic oxygen uptake and bacterial tetraether lipids in deep-sea trench regions.Nature communications · 2024Article
- Common origin of sterol biosynthesis points to a feeding strategy shift in Neoproterozoic animals.Nature communications · 2023Article
- An Overview of Lipid Biomarkers in Terrestrial Extreme Environments with Relevance for Mars Exploration.Astrobiology · 2023Review
- Incorporation, fate, and turnover of free fatty acids in cyanobacteria.FEMS microbiology reviews · 2023Review
- Palmitic Acid Inhibits the Growth and Metastasis of Gastric Cancer by Blocking the STAT3 Signaling Pathway.Cancers · 2023Article
- Lipidomic diversity and proxy implications of archaea from cold seep sediments of the South China Sea.Frontiers in microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fossilized lipids preserved in sedimentary rocks offer singular insights into the Earth's palaeobiology. These 'biomarkers' encode information pertaining to the oxygenation of the atmosphere and oceans, transitions in ocean plankton, the greening of continents, mass extinctions and climate change. Historically, biomarker interpretations relied on inventories of lipids present in extant microorganisms and counterparts in natural environments. However, progress has been impeded because only a small fraction of the Earth's microorganisms can be cultured, many environmentally significant microorganisms from the past no longer exist and there are gaping holes in knowledge concerning lipid biosynthesis. The revolution in genomics and bioinformatics has provided new tools to expand our understanding of lipid biomarkers, their biosynthetic pathways and distributions in nature. In this Review, we explore how preserved organic molecules provide a unique perspective on the history of the Earth's microbial life. We discuss how advances in molecular biology have helped elucidate biomarker origins and afforded more robust interpretations of fossil lipids and how the rock record provides vital calibration points for molecular clocks. Such studies are open to further exploitation with the expansion of sequenced microbial genomes in accessible databases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.