ArticleHypertension research : official journal of the Japanese Society of Hypertension2022
Lower systolic blood pressure levels in early pregnancy are associated with a decreased risk of early-onset superimposed preeclampsia in women with chronic hypertension: a multicenter retrospective study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Blood pressure-lowering treatment for pregnant women with non-severe hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Pooled it
- Gestational ages-specific blood pressure patterns and risk of adverse pregnancy outcomes in women with chronic hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Blood Pressure, Urinalysis, and Edema Assessment in Perinatal Care: From Historical Foundations to Evidence-Based Practice.JMA journal · 2026Review
- Article
- Differentiation of uterine fibroids and sarcomas by MRI and serum LDH levels: a multicenter study of the KAMOGAWA study.Journal of gynecologic oncology · 2025Article
- Stage 1 hypertension in early pregnancy: a key indicator of adverse perinatal outcomes.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Is an office blood pressure ≥140/90 mmHg an appropriate hypertension threshold for pregnant women?Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Time in therapeutic range for out-of-office blood pressure in hypertensive disorders of pregnancy: A better risk assessment measurement.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Chronic hypertension diagnosed before or during pregnancy and its effects on pregnancy outcomes.Journal of human hypertension · 2024Article
- Does Developing Interpregnancy Hypertension Affect the Recurrence Risk of Preeclampsia? A Population-Based Cohort Study.American journal of hypertension · 2024Article
- Maternal preconception blood pressure and the association with preterm birth.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- 2023 update and perspectives.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Preeclampsia up to date-What's going on?Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Ambulatory Blood Pressure Monitoring for Diagnosis and Management of Hypertension in Pregnant Women.Diagnostics (Basel, Switzerland) · 2023Review
- Update on Hypertension Research in 2021.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Tight control of blood pressure in pregnant women with nonsevere hypertension: expectations for decreasing adverse maternal and fetal pregnancy outcomes.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
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Authors and funding
20 authors at 14 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To clarify the impact of blood pressure (BP) management ranges on pregnancy outcomes, we conducted a multicenter retrospective analysis of 215 women with singleton pregnancies diagnosed with essential hypertension either before or within 14 weeks of gestation. Patients were classified according to systolic BP (sBP; <130, 130-139, 140-159, and ≥160 mmHg) or diastolic BP (dBP; <80, 80-89, 90-109, and ≥110 mmHg) at 8-11, 12-15, and 16-19 weeks of gestation. The risk of early-onset superimposed preeclampsia and small-for-gestational-age neonates was assessed in each BP group. Moreover, a subgroup analysis was performed in 144 eligible patients whose BP was measured at both 12-13 and 14-15 weeks of gestation. At 16-19 weeks of gestation, higher sBP significantly increased the incidence of early-onset superimposed preeclampsia (13.3%, 24.6%, 32.2% and 75.0%, respectively) and small-for-gestational-age neonates (6.0%, 13.1%, 16.9% and 50.0%, respectively). Multivariate logistic regression analyses showed that women with sBP < 130 mmHg at 16-19 weeks of gestation had a significantly lower risk of early-onset superimposed preeclampsia than women with sBP of 140-159 mmHg. Subgroup analyses also showed that even at 14-15 weeks of gestation, sBP < 130 mmHg was associated with a significantly lower risk of early-onset superimposed preeclampsia than an sBP of 140-159 mmHg. In conclusion, sBP < 130 mmHg within 14 weeks of gestation reduced the risk of developing early-onset superimposed preeclampsia in women with chronic hypertension.
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