SynthesisMolecular psychiatry2022
Inflammation and depression in young people: a systematic review and proposed inflammatory pathways.
Synthesis in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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Who cites it
52 citing papers in PubMed.
- Stressful life events and lifestyle factors are associated with elevated peripheral TNF-α levels in adults with depression without physical diseases.European archives of psychiatry and clinical neuroscience · 2026Article
- Peripheral Inflammation In Adult ADHD: Sex Differences And Hematological Markers.The Psychiatric quarterly · 2026Article
- The Dopaminergic Energy Crisis of Adolescent Depression: Mitochondrial Bioenergetics Control of Nucleus Accumbens Signaling.Neuroscience bulletin · 2026Article
- Associations between inflammation markers (CRP and IL-6) and depression among adolescents and young adults in Soweto and Durban, South Africa.Brain, behavior, & immunity - health · 2026Article
- Interpersonal stress, epigenetic indices of inflammation, and depressive symptoms: Longitudinal associations from adolescence to young adulthood.Neurobiology of stress · 2026Article
- Identifying neurodevelopmental signatures of worry: An ultra-high field (7-Tesla) fMRI study among adolescents and young adults.Developmental cognitive neuroscience · 2026Article
- Combining neurobiological markers and a sociodemographic risk score to predict adolescent depression - An IDEA RiSCo prospective cohort study.Molecular psychiatry · 2026Article
- Investigating the prospective associations of childhood sleep problems with persistent depression in emerging adulthood: the mediating role of inflammation.European child & adolescent psychiatry · 2026Article
- Decoding causal m6A: a bioinformatics roadmap for psychiatric disorders.Briefings in bioinformatics · 2026Review
- Psychobiological mechanisms underlying the association between early life stress and depression in adolescence.Molecular psychiatry · 2026Review
- Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi-Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The correlation between different types of negative life events and the mental health status of Han ethnic adolescents in Sichuan Province.Frontiers in psychiatry · 2026Article
- Interleukin-6 and tumor necrosis factor alpha as predictive biomarkers for depression and mania in young adults with depressive and bipolar disorder.Journal of psychiatric research · 2026Article
- White matter free water and depressive symptoms in medication-free depressed adolescents: moderation by peripheral inflammation.Translational psychiatry · 2025Article
- Adolescent depression, childhood maltreatment, and the immune system; a role for epigenetic aging?Brain, behavior, & immunity - health · 2025Article
- C-reactive protein is associated with pain-type somatic symptoms independent of mental health symptoms in adolescents: Evidence from the ALSPAC study.Brain, behavior, & immunity - health · 2025Article
- Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging.Nature communications · 2025Article
- Impact of physical activity on the incidence of psychiatric conditions during childhood: a longitudinal Swedish birth cohort study.British journal of sports medicine · 2025Article
- Association of remnant cholesterol with depression, type 2 diabetes, and their coexistence.BMC psychiatry · 2025Article
- Association of Children's Dietary Inflammatory Index with Depression and Anxiety Symptoms in Adolescents: Mediating Role of Inflammation and Cardiometabolic Risk Factors.Alpha psychiatry · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about inflammation in youth depression. This systematic review identified 109 studies examining the association between inflammation and youth depression and showed subtle evidence for inflammatory dysregulation in youth depression. Longitudinal studies support the bidirectional association between inflammation and depression in youth. We hypothesise multiple inflammatory pathways contributing to depression. More research is needed on anti-inflammatory treatments, potentially tailored to individual symptom profiles.
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